Miniaturized all-optical photoacoustic microscopy based on microelectromechanical systems mirror scanning

被引：42

作者：

Chen, Sung-Liang ^{[1
]}

Xie, Zhixing ^{[1
]}

Ling, Tao ^{[2
]}

Guo, L. Jay ^{[2
]}

Wei, Xunbin ^{[3
]}

Wang, Xueding ^{[1
]}

机构：

[1] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA

[3] Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China

来源：

OPTICS LETTERS | 2012年 / 37卷 / 20期

基金：

美国国家卫生研究院;

关键词：

BLADDER-CANCER; ANGIOGENESIS;

D O I：

10.1364/OL.37.004263

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Achieving photoacoustic microscopic imaging through a miniaturized scanning head is a crucial step toward high-resolution photoacoustic endoscopy. In this work, we have developed a miniaturized probe head using a microelectromechanical systems (MEMS) based mirror for raster scan of the laser beam and our newly developed super broad bandwidth microring resonator based ultrasound detector for photoacoustic signal detection. Through this all-optical design, which offers unique advantages for endoscopic applications, this system is capable of three-dimensional (3D) imaging with high resolution of 17.5 mu m in lateral direction and 20 mu m in axial direction at a distance of 3.7 mm. After the performance of this system was validated through the experiments on printed grids and a resolution test target, microscopic imaging of the 3D microvasculatures in canine bladders was also conducted successfully, demonstrating the potential of novel photoacoustic endoscopic in future clinical management of bladder cancer. (C) 2012 Optical Society of America

引用

页码：4263 / 4265

页数：3

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