Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function

被引:80
|
作者
Papa, Sergio [1 ,2 ]
De Rasmo, Domenico [1 ]
Scacco, Salvatore [1 ]
Signorile, Anna [1 ]
Technikova-Dobrova, Zuzana [4 ]
Palmisano, Giuseppe [1 ]
Sardanelli, Anna Maria [1 ]
Papa, Francesco [3 ]
Panelli, Damiano [1 ]
Scaringi, Raffaella [1 ]
Santeramo, Arcangela [1 ]
机构
[1] Univ Bari, Dept Med Biochem Biol & Phys, I-70124 Bari, Italy
[2] CNR, IBBE, I-00185 Rome, Italy
[3] Univ Bari, Dept Odontostomatol & Surg, I-70124 Bari, Italy
[4] Acad Sci Czech Republic, Inst Microbiol, Prague, Czech Republic
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2008年 / 1777卷 / 7-8期
关键词
complex I; proton pump; cAMP cascade; PKA; mitochondrial import; mitochondrial phosphoproteome;
D O I
10.1016/j.bbabio.2008.04.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In this paper the regulatory features of complex I of mammalian and human mitochondria are reviewed. In a variety of mitotic cell-line cultures, activation in vivo of the cAMP cascade, or direct addition of cAMP, promotes the NADH-ubiquinone oxidoreductase activity of complex I and lower the cellular level of ROS. These effects of cAMP are found to be associated with PKA-mediated serine phosphorylation in the conserved C-terminus of the subunit of complex I encoded by the nuclear gene NDUFS4. PKA mediated phosphorylation of this Ser in the C-terminus of the protein promotes its mitochondrial import and maturation. Mass-spectrometry analysis of the phosphorylation pattern of complex I subunits is also reviewed. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:719 / 728
页数:10
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