Polyacetylenes from terrestrial plants and fungi: Recent phytochemical and biological advances

被引:87
作者
Negri, Roberto [1 ]
机构
[1] Univ Piemonte Orientale, Dipartimento Sci Farm, I-28100 Novara, Italy
关键词
Polyacetylenes; Isolation; Plants; Fungi; Bioactivity; BIOACTIVE CONSTITUENTS; CHEMICAL-CONSTITUENTS; CYTOTOXIC POLYACETYLENES; INHIBITORY-ACTIVITY; GABAERGIC CURRENTS; AERIAL PARTS; ENDOCANNABINOID SYSTEM; ATRACTYLODES-CHINENSIS; STRUCTURAL ELUCIDATION; THIOPHENE ACETYLENES;
D O I
10.1016/j.fitote.2015.08.011
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Polyacetylenes are a class of polyketides related to fatty acids that occur in plants, fungi, marine organisms and animals. These compounds show a pleiotropic profile of bioactivity, that includes antitumor, antibacterial, antimicrobial or antifungal properties. Because of this, the literature on these compounds has grown exponentially, and this review aims at summarizing the inventory of polyacetylenes occurring in terrestrial eukaryotic organisms (plants and fungi) during the last 15 years, and at discussing progress in their bioactivities and in the identification of their biological targets. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:92 / 109
页数:18
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