Polycations. 18. The synthesis of polycationic lipid materials based on the diamine 1,4-diazabicyclo[2.2.2]octane

被引：27

作者：

Engel, Robert ^{[1
]}

Rizzo, JaimeLee Iolani ^{[2
]}

Rivera, Christina ^{[2
]}

Ramirez, Mariah ^{[1
]}

Huang, Mia Lace ^{[1
]}

Montenegro, Diego ^{[1
]}

Copodiferro, Craig ^{[1
]}

Behaj, Valbona ^{[1
]}

Thomas, Marie ^{[1
,3
]}

Klaritch-Vrana, Barbara ^{[1
]}

Engel, Jeanne Fabian ^{[1
]}

机构：

[1] CUNY Queens Coll, Dept Chem & Biochem, Flushing, NY 11367 USA

[2] Pace Univ, Dept Chem & Phys Sci, New York, NY 10038 USA

[3] CUNY, Grad Ctr, Doctoral Program Chem, New York, NY 10016 USA

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2009年 / 158卷 / 01期

关键词：

Cationic lipid; Dabco; Antimicrobial; Polycation; Quaternary ammonium salt; Antihydrophobic effect; CATIONIC BILAYER FRAGMENTS; AMPHOTERICIN-B FORMULATION; LIQUID IONIC PHOSPHATES; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; PHOSPHONIUM SALTS; PEPTIDES; BACTERIA; VESICLES; STRINGS;

D O I：

10.1016/j.chemphyslip.2008.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein is reported the preparation of several series of polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on the parent diamine 1,4-diazabicyclo[2.2.2]octane (dabco).Through selective alkylation of dabco a variety of di-and tetracationic lipid species and precursors thereof have been prepared. The resultant materials are of significant interest for a variety of purposes, including serving as antimicrobial agents and antihydrophobic species, the details of which are provided in separate reports. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 69

页数：9

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