Epidural butorphanol-bupivacaine analgesia for postoperative pain relief after abdominal hysterectomy

Study Objective: To determine the efficacy Of epidural butorphanol With and without bupivacaine in providing postoperative analgesia following abdominal hysterectomy. Design: Randomized, double-blinded study. Settings: Postoperative recovery area of a university-affiliated medical center. Patients: 60 ASA physical status I and II women, aged 20-65 years, undergoing abdominal hysterectomy. Interventions: Patients were randomly allocated to three groups during,1 the postoperative period to receive one of three epidural regiments: two mg of butorphanol in 10 mL of normal saline (Group I), two mg of butorphanol in 10 mL of 0.125% bupivacaine (Group 2), or two mg of butorphanol in 10 mL of 0.25% bupivacaine (Group 3). Measurements: Onset and duration of analgesia were recorded. Hemodynamic variables, pain scores. sedation scores, and respiratory rate were monitored for 24 hours. Frequency and severity of respiratory. depression, sedation, pruritus, nausea, and vomiting were recorded. Main Results: The addition of butorphanol to bupivacaine resulted in significantly (P < 0.05) faster onset of pain relief. The duration of analgesia was prolonged in patients receiving butorphanol with bupivacaine combination (8.68 +/- 0.82 hrs. 9.82 +/- 0.54 firs) as compared with butorphanol alone (4.35 +/- 0.66 hrs; P < 0.05). The differences between Groups 2 and 3 were not significant. Conclusions: Addition of two mg of butorphanol to 0.125% of epidural bupivacaine resulted in rapid onset and longer duration of analgesia than did butorphanol alone. (c) 2009 Elsevier Inc. All rights reserved.