A Novel Bioabsorbable Gel Formed from a Mixed Micelle Solution of Poly(oxyethylene)-block-poly(L-lactide) and Poly(oxyethylene)-block-poly(D-lactide) by Concomitant Stereocomplexation and Chain Extension

被引：10
|
作者：
Hsu, Yu-I [1 ]
Masutani, Kazunari [1 ]
Kimura, Yoshiharu [1 ]
Yamaoka, Tetsuji [2 ]
机构：
[1] Kyoto Inst Technol, Dept Biobased Mat Sci, Kyoto 6068585, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Suita, Osaka 5658565, Japan
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2013年 / 214卷 / 14期
关键词：
Diels-Alder reaction; polyethylene glycol; polylactide; sol-gel transition; stereocomplexation; PLA NANOPARTICLES; DELIVERY; COPOLYMERS; HYDROGELS; POLYLACTIDES;
D O I：
10.1002/macp.201300230
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Furan-terminated poly(oxyethylene)-block-poly(L-lactide) (MePEG-PLLA-F) and poly(oxyethylene)-block-poly(D-lactide) (MePEG-PDLA-F) are synthesized by ring-opening polymerization of L- and D-lactides, respectively, in the presence of poly(ethylene glycol) monomethyl ether (MePEG) and the following terminal reaction with furfuryl isocyanate. Their mixed micelle solution turns to gel quickly with stereocomplexation of the enantiomeric PLLA and PDLA. When 1,8-bis(maleimido)diethylene glycol (BMG) is added to the mixed micelle solution, the gelation is promoted by the terminal coupling of the copolymers driven by the Diels-Alder reaction of the furanyl groups and BMG giving a gel having higher strength.
引用
收藏
页码：1559 / 1568
页数：10
相关论文
共 50 条
  • [1] Linear and Four-Armed Poly(L-lactide)-block-poly(D-lactide) Copolymers and Their Stereocomplexation with Poly(lactide)s
    Shao, Jun
    Tang, Zhaohui
    Sun, Jingru
    Li, Gao
    Chen, Xuesi
    JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2014, 52 (23) : 1560 - 1567
  • [2] Carbon Nanotube Grafted Poly(L-lactide)-block-poly(D-lactide) and Its Stereocomplexation with Poly(lactide)s: The Nucleation Effect of Carbon Nanotubes
    Cao, Zhi-Qiang
    Sun, Xiao-Rong
    Bao, Rui-Ying
    Yang, Wei
    Xie, Bang-Hu
    Yang, Ming-Bo
    ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2016, 4 (05): : 2660 - 2669
  • [3] Crystallization Studies on the Stereocomplexation of Poly(L-lactide)/4-Armed Poly(ε-caprolactone-co-D,L-lactide)- block-poly(D-lactide) Blends
    Jin, Tingting
    Dai, Suyang
    Wang, Xiangyu
    Jiang, Ni
    Ning, Zhenbo
    Gan, Zhihua
    CHEMISTRYSELECT, 2023, 8 (30):
  • [4] VISCOMETRIC CHARACTERIZATION OF POLY(OXYETHYLENE)-BLOCK-POLY(OXYPROPYLENE)-BLOCK-POLY(OXYETHYLENE) IN AQUEOUS-SOLUTION
    BLASS, P
    HERGETH, WD
    WOHLFARTH, C
    WARTEWIG, S
    MAKROMOLEKULARE CHEMIE-MACROMOLECULAR CHEMISTRY AND PHYSICS, 1992, 193 (04): : 957 - 973
  • [5] Novel block-poly(L-lactide)-block-poly(ε-caprolactone)-block-poly(L-lactide) systems designed to remove small organic pollutants from aqueous environments
    Bernhardt, Katrina
    Balija, Amy
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [6] Highly stabilized nanostructures from poly(L-lactide)-block-poly(oxyethylene) having a photoreactive end functionality
    Fujiwara, T
    Iwata, T
    Kimura, Y
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2001, 39 (24) : 4249 - 4254
  • [7] Relationship between crystallization state and degradation behavior of poly(l-lactide)/four-armed poly(d,l-lactide)-block-poly(d-lactide) blends with different poly(d-lactide) block lengths
    Dai, Suyang
    Jiang, Ni
    Ning, Zhenbo
    Gan, Zhihua
    POLYMER INTERNATIONAL, 2021, 70 (05) : 667 - 678
  • [8] Crystallization and Alkaline Degradation Behaviors of Poly(l-Lactide)/4-Armed Poly(ε-Caprolactone)-Block-Poly(d-Lactide) Blends with Different Poly(d-Lactide) Block Lengths
    Dai, Suyang
    Wang, Min
    Zhuang, Zhuoxin
    Ning, Zhenbo
    POLYMERS, 2020, 12 (10)
  • [9] Quantitative analysis of biodegradable amphipmlic poly(L-lactide)-block-poly(ethyleneglycol)-block-poly(L-lactide) by using TG, FTIR and NMR
    Drumond, W. S.
    Mothe, C. G.
    Wang, S. H.
    JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2006, 85 (01) : 173 - 177
  • [10] Fabrication of poly(L-lactide)-block-poly(ethylene glycol)-block-poly(L-lactide) triblock copolymer thin flims with nanochannels: An AFM study
    Choi, Sung-Wook
    Kim, Yongwoo
    Cheong, In Woo
    Kim, Jung-Hyun
    MACROMOLECULAR RAPID COMMUNICATIONS, 2008, 29 (02) : 175 - 180
12345