A Novel Bioabsorbable Gel Formed from a Mixed Micelle Solution of Poly(oxyethylene)-block-poly(L-lactide) and Poly(oxyethylene)-block-poly(D-lactide) by Concomitant Stereocomplexation and Chain Extension

被引：10
作者：
Hsu, Yu-I [1 ]
Masutani, Kazunari [1 ]
Kimura, Yoshiharu [1 ]
Yamaoka, Tetsuji [2 ]
机构：
[1] Kyoto Inst Technol, Dept Biobased Mat Sci, Kyoto 6068585, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Suita, Osaka 5658565, Japan
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2013年 / 214卷 / 14期
关键词：
Diels-Alder reaction; polyethylene glycol; polylactide; sol-gel transition; stereocomplexation; PLA NANOPARTICLES; DELIVERY; COPOLYMERS; HYDROGELS; POLYLACTIDES;
D O I：
10.1002/macp.201300230
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Furan-terminated poly(oxyethylene)-block-poly(L-lactide) (MePEG-PLLA-F) and poly(oxyethylene)-block-poly(D-lactide) (MePEG-PDLA-F) are synthesized by ring-opening polymerization of L- and D-lactides, respectively, in the presence of poly(ethylene glycol) monomethyl ether (MePEG) and the following terminal reaction with furfuryl isocyanate. Their mixed micelle solution turns to gel quickly with stereocomplexation of the enantiomeric PLLA and PDLA. When 1,8-bis(maleimido)diethylene glycol (BMG) is added to the mixed micelle solution, the gelation is promoted by the terminal coupling of the copolymers driven by the Diels-Alder reaction of the furanyl groups and BMG giving a gel having higher strength.
引用
收藏
页码：1559 / 1568
页数：10
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