Effects of low-dose dopamine on urine output in normotensive very low birth weight neonates

被引：7
|
作者：
Crouchley, J. L. [1 ]
Smith, P. B. [1 ]
Cotten, C. M. [1 ]
Hornik, C. D. [1 ]
Goldberg, R. N. [1 ]
Foreman, J. W. [1 ]
Wynn, J. L. [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA
来源：
JOURNAL OF PERINATOLOGY | 2013年 / 33卷 / 08期
关键词：
renal dose; dopamine; urine output; ACUTE-RENAL-FAILURE; INTENSIVE-CARE; INFUSION; PRETERM; NEWBORNS; INFANTS; PERIOD;
D O I：
10.1038/jp.2013.20
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates. STUDY DESIGN: Retrospective cohort study of all low-dose (3-5 mu g kg(-1) per min) dopamine infusions >24-h duration in neonates <= 1500 g and <= 32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP. RESULT: We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg(-1) h(-1) increase in UOP (P<0.001) and a 1.3 ml kg(-1) h(-1) increase when baseline UOP was <1.5 ml kg(-1) h(-1) (P<0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake. CONCLUSION: Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.
引用
收藏
页码：619 / 621
页数：3
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