Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3′-diindolylmethane ligand

被引：29

作者：

Dankhoff, Katja ^{[1
]}

Ahmad, Aamir ^{[2
]}

Weber, Birgit ^{[1
]}

Biersack, Bernhard ^{[3
]}

Schobert, Rainer ^{[3
]}

机构：

[1] Univ Bayreuth, Inorgan Chem 4, Univ Str 30, D-95447 Bayreuth, Germany

[2] USA Mitchell Canc Inst, 1660 Springhill Ave, Mobile, AL 36604 USA

[3] Univ Bayreuth, Organ Chem Lab, Univ Str 30, D-95447 Bayreuth, Germany

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2019年 / 194卷

关键词：

Vanadium; Diindolylmethane; Anticancer drugs; Reactive oxygen species; DNA binding; BREAST-CANCER CELLS; V-IV; APOPTOSIS; ACTIVATION; CHEMISTRY; GROWTH; AGENTS; OXOVANADIUM(IV); CYTOTOXICITY; REDUCTION;

D O I：

10.1016/j.jinorgbio.2019.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate (IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondria] damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells.

引用

页码：1 / 6

页数：6

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