On and Off Retinal Circuit Assembly by Divergent Molecular Mechanisms

被引：106

作者：

Sun, Lu O. ^{[1
,2
]}

Jiang, Zheng ^{[1
]}

Rivlin-Etzion, Michal ^{[3
,4
]}

Hand, Randal ^{[1
,2
]}

Brady, Colleen M. ^{[1
,2
]}

Matsuoka, Ryota L. ^{[1
,2
]}

Yau, King-Wai ^{[1
]}

Feller, Marla B. ^{[3
,4
]}

Kolodkin, Alex L. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

SCIENCE | 2013年 / 342卷 / 6158期

关键词：

DIRECTION-SELECTIVITY; AMACRINE CELLS; ORGANIZATION; LAMINATION; PLEXIN-A2; DENDRITES;

D O I：

10.1126/science.1241974

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Direction-selective responses to motion can be to the onset (On) or cessation (Off) of illumination. Here, we show that the transmembrane protein semaphorin 6A and its receptor plexin A2 are critical for achieving radially symmetric arborization of On starburst amacrine cell (SAC) dendrites and normal SAC stratification in the mouse retina. Plexin A2 is expressed in both On and Off SACs; however, semaphorin 6A is expressed in On SACs. Specific On-Off bistratified direction- selective ganglion cells in semaphorin 6A(-/-) mutants exhibit decreased tuning of On directional motion responses. These results correlate the elaboration of symmetric SAC dendritic morphology and asymmetric responses to motion, shedding light on the development of visual pathways that use the same cell types for divergent outputs.

引用

页码：590 / +

页数：10

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