CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia

被引:253
作者
Green, Margaret L. [1 ,2 ]
Leisenring, Wendy M. [3 ,4 ]
Xie, Hu [3 ]
Walter, Roland B. [2 ,3 ]
Mielcarek, Marco [2 ,3 ]
Sandmaier, Brenda M. [2 ,3 ]
Riddell, Stanley R. [2 ,3 ]
Boeckh, Michael [1 ,2 ,3 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA
[2] Univ Washington, Dept Med, Seattle, WA USA
[3] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
[4] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
基金
美国国家卫生研究院;
关键词
STEM-CELL TRANSPLANTATION; CYTOMEGALOVIRUS DISEASE; MARROW TRANSPLANTATION; TREATMENT STRATEGY; REDUCED-INTENSITY; KIR REPERTOIRE; BONE-MARROW; NK CELLS; DONOR; RECIPIENTS;
D O I
10.1182/blood-2013-02-487074
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The association between cytomegalovirus (CMV) reactivation and relapse was evaluated in a large cohort of patients with acute myeloid leukemia (AML) (n = 761), acute lymphoblastic leukemia (ALL) (n = 322), chronic myeloid leukemia (CML) (n = 646), lymphoma (n = 254), and myelodysplastic syndrome (MDS) (n = 371) who underwent allogeneic hematopoietic cell transplantation (HCT) between 1995 and 2005. In multivariable models, CMV pp65 antigenemia was associated with a decreased risk of relapse by day 100 among patients with AML (hazard ratio [HR] = 0.56; 95% confidence interval [CI], 0.3-0.9) but not in patients with ALL, lymphoma, CML, or MDS. The effect appeared to be independent of CMV viral load, acute graft-versus-host disease, or ganciclovir-associated neutropenia. At 1 year after HCT, early CMV reactivation was associated with reduced risk of relapse in all patients, but this did not reach significance for any disease subgroup. Furthermore, CMV reactivation was associated with increased nonrelapse mortality (HR = 1.31; 95% CI, 1.1-1.6) and no difference in overall mortality (HR = 1.05; 95% CI, 0.9-1.3). This report demonstrates a modest reduction in early relapse risk after HCT associated with CMV reactivation in a large cohort of patients without a benefit in overall survival.
引用
收藏
页码:1316 / 1324
页数:9
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