1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase

被引：4
|
作者：
Machado, Luciana E. S. F. [1 ,3 ]
Page, Rebecca [2 ,3 ]
Peti, Wolfgang [1 ,3 ]
机构：
[1] Brown Univ, Dept Mol Pharmacol Physiol & Biotechnol, Providence, RI 02912 USA
[2] Brown Univ, Dept Mol Biol Cell Biol & Biochem, Providence, RI 02912 USA
[3] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA
来源：
BIOMOLECULAR NMR ASSIGNMENTS | 2018年 / 12卷 / 01期
关键词：
HePTP; Protein tyrosine phosphatase; Vanadate; Inhibition; Protein dynamics; Leukemia; PROTEIN; EXPRESSION; P38-ALPHA; HEPTP;
D O I：
10.1007/s12104-017-9770-7
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The sequence-specific backbone assignment of hematopoietic protein tyrosine phosphatase (HePTP; PTPN7) in presence of vanadate has been determined, based on triple-resonance experiments using uniformly [C-13,N-15]-labeled protein. These assignments facilitate further studies of HePTP in the presence of inhibitors to target leukemia and provide further insights into the function of protein tyrosine phosphatases.
引用
收藏
页码：5 / 9
页数：5
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