Expression and significance of Caspase-8 in non-small cell lung cancer(NSCLC)

Objective: RCAS1, Caspase-8 expression in non-small cell lung cancer and its significance. Methods: the soluble RCAS1 in our hospital between February 2009 to February 2010, included 40 patients with non-small cell lung cancer, the expression of caspase-8 protein taken immunohistochemistry method were measured, and select the normal lung tissue RCAS1 Caspase-8 protein expression compared. Results: There are two comparative analysis, the positive expression rate of tumor patients RCAS1 RCAS1 positive expression rate was significantly higher than the two sets of data was statistically significant (P <0.05); Oncology Group of Caspase-8 positive the expression rate Caspase-8 positive expression rate was significantly lower than the control group data in two groups was statistically significant (P <0.05). Correlation analysis of protein expression in non-small cell lung cancer, the soluble RCAS1 Caspase-8 expression in non-small cell lung cancer negative correlation (r = -0.121, P <0.05). Conclusion: the soluble RCAS1 Caspase-8 protein in non-small cell lung cancer in the abnormal expression of the disease can be used as an important diagnostic marker, has important applications in clinical.