Defining Common Variable Immunodeficiency Disorders in 2020

被引:41
作者
Ameratunga, Rohan [1 ,2 ,3 ,4 ]
Allan, Caroline [1 ]
Woon, See-Tarn [1 ,4 ]
机构
[1] Auckland City Hosp, Dept Virol & Immunol, Auckland, New Zealand
[2] Auckland Healthcare Serv, Pk Rd, Auckland 1010, New Zealand
[3] Auckland City Hosp, Clin Immunol, Auckland, New Zealand
[4] Univ Auckland, Fac Med & Hlth Sci, Dept Mol Med & Pathol, Auckland, New Zealand
关键词
Common variable immunodeficiency; Diagnostic criteria; HGUS; THA; CVID; SCIG; IVIG; Hypogammaglobulinemia; NODULAR REGENERATIVE HYPERPLASIA; PNEUMOCOCCAL CONJUGATE; DIAGNOSTIC-CRITERIA; PRIMARY HYPOGAMMAGLOBULINEMIA; SUBCLASS DEFICIENCY; ANTIBODY-RESPONSE; VACCINATION; DISEASE; IMMUNOGENICITY; REVACCINATION;
D O I
10.1016/j.iac.2020.03.001
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Common variable immunodeficiency disorders (CVID) are the most frequent symptomatic primary immune deficiency in adults. Because there is no known cause for these conditions, there is no single clinical feature or laboratory test that can confirm the diagnosis with certainty. If a causative mutation is identified, patients are deemed to have a CVID-like disorder caused by a specific primary immunodeficiency/inborn error of immunity. In the remaining patients, the explanation for these disorders remains unclear. The understanding of CVID continues to evolve and the authors review recent studies, which have addressed some of these uncertainties.
引用
收藏
页码:403 / +
页数:19
相关论文
共 50 条
  • [21] Diagnostic criteria for common variable immunodeficiency disorders
    Ameratunga, Rohan
    Gillis, David
    Steele, Richard
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2016, 4 (05) : 1017 - 1018
  • [22] The role of genomics in common variable immunodeficiency disorders
    Kienzler, A. -K.
    Hargreaves, C. E.
    Patel, S. Y.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2017, 188 (03) : 326 - 332
  • [23] The Immune Dysregulation of Common Variable Immunodeficiency Disorders
    Fernando, Suran L.
    Jang, Helena S-, I
    Li, Jamma
    [J]. IMMUNOLOGY LETTERS, 2021, 230 : 21 - 26
  • [24] The autoimmune conundrum in common variable immunodeficiency disorders
    van de Ven, Annick A. J. M.
    Warnatz, Klaus
    [J]. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 15 (06) : 514 - 524
  • [25] Pulmonary Manifestations of Common Variable Immunodeficiency
    Bang, Tami J.
    Richards, John Caleb
    Olson, Amy L.
    Groshong, Steve D.
    Gelfand, Erwin W.
    Lynch, David A.
    [J]. JOURNAL OF THORACIC IMAGING, 2018, 33 (06) : 377 - 383
  • [26] Neurologic Complications of Common Variable Immunodeficiency
    Nguyen, Jenna Thuc-Uyen
    Green, Ari
    Wilson, Michael R.
    DeRisi, Joseph L.
    Gundling, Katherine
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2016, 36 (08) : 793 - 800
  • [27] Pathogenesis of autoimmunity in common variable immunodeficiency
    Warnatz, Klaus
    Voll, Reinhard E.
    [J]. FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [28] Common Variable Immunodeficiency
    Remiker, Allison
    Bolling, Kristina
    Verbsky, James
    [J]. MEDICAL CLINICS OF NORTH AMERICA, 2024, 108 (01) : 107 - 121
  • [29] Common variable immunodeficiency
    Tam, Jonathan S.
    Routes, John M.
    [J]. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, 2013, 27 (04) : 260 - 265
  • [30] Common variable immunodeficiency
    Cunningham-Rundles, Charlotte
    Maglione, Paul J.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (05) : 1425 - U407