Defining Common Variable Immunodeficiency Disorders in 2020

被引：45

作者：

Ameratunga, Rohan ^{[1
,2
,3
,4
]}

Allan, Caroline ^{[1
]}

Woon, See-Tarn ^{[1
,4
]}

机构：

[1] Auckland City Hosp, Dept Virol & Immunol, Auckland, New Zealand

[2] Auckland Healthcare Serv, Pk Rd, Auckland 1010, New Zealand

[3] Auckland City Hosp, Clin Immunol, Auckland, New Zealand

[4] Univ Auckland, Fac Med & Hlth Sci, Dept Mol Med & Pathol, Auckland, New Zealand

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2020年 / 40卷 / 03期

关键词：

Common variable immunodeficiency; Diagnostic criteria; HGUS; THA; CVID; SCIG; IVIG; Hypogammaglobulinemia; NODULAR REGENERATIVE HYPERPLASIA; PNEUMOCOCCAL CONJUGATE; DIAGNOSTIC-CRITERIA; PRIMARY HYPOGAMMAGLOBULINEMIA; SUBCLASS DEFICIENCY; ANTIBODY-RESPONSE; VACCINATION; DISEASE; IMMUNOGENICITY; REVACCINATION;

D O I：

10.1016/j.iac.2020.03.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Common variable immunodeficiency disorders (CVID) are the most frequent symptomatic primary immune deficiency in adults. Because there is no known cause for these conditions, there is no single clinical feature or laboratory test that can confirm the diagnosis with certainty. If a causative mutation is identified, patients are deemed to have a CVID-like disorder caused by a specific primary immunodeficiency/inborn error of immunity. In the remaining patients, the explanation for these disorders remains unclear. The understanding of CVID continues to evolve and the authors review recent studies, which have addressed some of these uncertainties.

引用

页码：403 / +

页数：19

共 70 条

[1]

Abolhassani H, 2020, BLOOD, V15

[2] Immunological and clinical profile of adult patients with selective immunoglobulin subclass deficiency: response to intravenous immunoglobulin therapy [J].

Abrahamian, F. ;

Agrawal, S. ;

Gupta, S. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2010, 159 (03) :344-350

[3]

Ameratunga R, 2000, PATHOLOGY, V32, P280

[4] Transient hypogammaglobulinaemia of infancy: many patients recover in adolescence and adulthood [J].

Ameratunga, R. ;

Ahn, Y. ;

Steele, R. ;

Woon, S. -T. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2019, 198 (02) :224-232

[5] New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin [J].

Ameratunga, R. ;

Woon, S. -T. ;

Gillis, D. ;

Koopmans, W. ;

Steele, R. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2013, 174 (02) :203-211

[6]

Ameratunga R, 2015, Clin Exp Neuroimmunol, V6, P83, DOI DOI 10.1111/CEN3.12135

[7] The critical role of histology in distinguishing sarcoidosis from common variable immunodeficiency disorder (CVID) in a patient with hypogammaglobulinemia [J].

Ameratunga, Rohan ;

Ahn, Yeri ;

Tse, Dominic ;

Woon, See-Tarn ;

Pereira, Jennifer ;

McCarthy, Sinead ;

Blacklock, Hilary .

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 2019, 15 (01)

[8] Perspective: Evolving Concepts in the Diagnosis and Understanding of Common Variable Immunodeficiency Disorders (CVID) [J].

Ameratunga, Rohan ;

Woon, See-Tarn .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2020, 59 (01) :109-121

[9] The Natural History of Untreated Primary Hypogammaglobulinemia in Adults: Implications for the Diagnosis and Treatment of Common Variable Immunodeficiency Disorders (CVID) [J].

Ameratunga, Rohan ;

Ahn, Yen ;

Steele, Richard ;

Woon, See-Tarn .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[10] Assessing Disease Severity in Common Variable Immunodeficiency Disorders (CVID) and CVID-Like Disorders [J].

Ameratunga, Rohan .

FRONTIERS IN IMMUNOLOGY, 2018, 9

← 1 2 3 4 5 6 7 →