Nitric oxide and vascular reactivity in sepsis

被引：66

作者：

Fernandes, Daniel ^{[1
]}

Assreuy, Jamil ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Pharmacol, Ctr Biol Sci, BR-88049900 Florianopolis, SC, Brazil

来源：

SHOCK | 2008年 / 30卷

关键词：

potassium channels; guanylate cyclase; blood pressure; vasoplegia; septic shock;

D O I：

10.1097/SHK.0b013e3181818518

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Sepsis and septic shock are major causes of morbidity and mortality in critically ill patients. Sepsis and septic shock induce a profound fall in the peripheral vascular tone. NO has been implicated as a key player in vascular changes of sepsis and septic shock. In this brief review, two points are focused in greater detail: first, the involvement of guanylate cyclase and potassium channels in NO vascular effects in sepsis; second, the role played by NO and its two effectors in the long-lasting modifications of vascular reactivity in sepsis. Some recent developments in the area are reviewed.

引用

页码：10 / 13

页数：4

共 63 条

[1] Nitric oxide synthases: structure, function and inhibition [J].

Alderton, WK ;

Cooper, CE ;

Knowles, RG .

BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615

[2] Use of methylene blue in patients with refractory septic shock:: Impact on hemodynamics and gas exchange [J].

Andresen, M ;

Dougnac, A ;

Díaz, O ;

Hernández, G ;

Castillo, L ;

Bugedo, G ;

Alvarez, M ;

Dagnino, J .

JOURNAL OF CRITICAL CARE, 1998, 13 (04) :164-168

[3] NITRIC-OXIDE AND CGMP CAUSE VASORELAXATION BY ACTIVATION OF A CHARYBDOTOXIN-SENSITIVE K-CHANNEL BY CGMP-DEPENDENT PROTEIN-KINASE [J].

ARCHER, SL ;

HUANG, JMC ;

HAMPL, V ;

NELSON, DP ;

SHULTZ, PJ ;

WEIR, EK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7583-7587

[4] NITRIC-OXIDE DIRECTLY ACTIVATES CALCIUM-DEPENDENT POTASSIUM CHANNELS IN VASCULAR SMOOTH-MUSCLE [J].

BOLOTINA, VM ;

NAJIBI, S ;

PALACINO, JJ ;

PAGANO, PJ ;

COHEN, RA .

NATURE, 1994, 368 (6474) :850-853

[5]

Brandtzaeg P, 1996, CURR TOP MICROBIOL, V216, P15

[6] Continuous infusion of methylene blue for septic shock [J].

Brown, G ;

Frankl, D ;

Phang, T .

POSTGRADUATE MEDICAL JOURNAL, 1996, 72 (852) :612-614

[7] Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity [J].

Cauwels, Anje ;

Brouckaert, Peter .

SHOCK, 2008, 29 (05) :577-582

[8] Shortening of cardiac action potentials in endotoxic shock in guinea pigs is caused by an increase in nitric oxide activity and activation of the adenosine triphosphate-sensitive potassium channel [J].

Chen, CC ;

Lin, YC ;

Chen, SA ;

Luk, HN ;

Ding, PYA ;

Chang, MS ;

Chiang, CE .

CRITICAL CARE MEDICINE, 2000, 28 (06) :1713-1720

[9] Abnormal activation of K+ channels in aortic smooth muscle of rats with endotoxic shock:: electrophysiological and functional evidence [J].

Chen, SJ ;

Wu, CC ;

Yang, SN ;

Lin, CI ;

Yen, MH .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (02) :213-222

[10] Role of nitric oxide and K+-channels in vascular hyporeactivity induced by endotoxin [J].

Chen, SJ ;

Wu, CC ;

Yen, MH .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1999, 359 (06) :493-499

← 1 2 3 4 5 6 7 →