Present Status of Adjuvant Chemotherapy for Elderly Breast Cancer Patients

被引：4

作者：

Loibl, Sibylle ^{[1
,2
]}

Reinisch, Mattea ^{[1
,3
]}

机构：

[1] German Breast Grp, Neu Isenburg, Germany

[2] Stadt Kliniken Offenbach, Offenbach, Germany

[3] Burgerhosp Frankfurt M, Frauenklin, Frankfurt, Germany

来源：

BREAST CARE | 2012年 / 7卷 / 06期

关键词：

Adjuvant chemotherapy; Elderly patients; Breast cancer; OLDER WOMEN; EUROPEAN COUNTRIES; CAPECITABINE X; IBANDRONATE I; PATIENTS PTS; DOCETAXEL; TRIAL; RECOMMENDATIONS; MULTICENTER; MANAGEMENT;

D O I：

10.1159/000345867

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Elderly breast cancer patients are underrepresented in clinical trials, leading to a lack of knowledge regarding their tolerance of modern chemotherapy regimens. In addition, physicians are often reluctant to treat older patients with chemotherapy due to potential side effects. This article summarizes the up-to-date literature on chemotherapy in elderly patients with breast cancer, evaluates the impact of the patients' comorbidities and treatment alterations and aims to encourage treating patients adequately according to their disease in combination with the biological age rather than the chronological age alone. Finally, a short overview is given of the recruiting studies in Europe evaluating chemotherapy in elderly patients.

引用

页码：439 / 444

页数：6

共 41 条

[1] 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours [J].

Aapro, M. S. ;

Bohlius, J. ;

Cameron, D. A. ;

Dal Lago, Lissandra ;

Donnelly, J. Peter ;

Kearney, N. ;

Lyman, G. H. ;

Pettengell, R. ;

Tjan-Heijnen, V. C. ;

Walewski, J. ;

Weber, Damien C. ;

Zielinski, C. .

EUROPEAN JOURNAL OF CANCER, 2011, 47 (01) :8-32

[2] Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials [J].

Albain, K. ;

Anderson, S. ;

Arriagada, R. ;

Barlow, W. ;

Bergh, J. ;

Bliss, J. ;

Buyse, M. ;

Cameron, D. ;

Carrasco, E. ;

Clarke, M. ;

Correa, C. ;

Coates, A. ;

Collins, R. ;

Costantino, J. ;

Cutter, D. ;

Cuzick, J. ;

Darby, S. ;

Davidson, N. ;

Davies, C. ;

Davies, K. ;

Delmestri, A. ;

Di Leo, A. ;

Dowsett, M. ;

Elphinstone, P. ;

Evans, V. ;

Ewertz, M. ;

Gelber, R. ;

Gettins, L. ;

Geyer, C. ;

Goldhirsch, A. ;

Godwin, J. ;

Gray, R. ;

Gregory, C. ;

Hayes, D. ;

Hill, C. ;

Ingle, J. ;

Jakesz, R. ;

James, S. ;

Kaufmann, M. ;

Kerr, A. ;

MacKinnon, E. ;

McGale, P. ;

McHugh, T. ;

Norton, L. ;

Ohashi, Y. ;

Paik, S. ;

Pan, H. C. ;

Perez, E. ;

Peto, R. ;

Piccart, M. .

LANCET, 2012, 379 (9814) :432-444

[3] Early breast cancer in the elderly - Assessment and management considerations [J].

Albrand, Gilles ;

Terret, Catherine .

DRUGS & AGING, 2008, 25 (01) :35-45

[4] Disparities in breast cancer mortality trends between 30 European countries: retrospective trend analysis of WHO mortality database [J].

Autier, Philippe ;

Boniol, Mathieu ;

LaVecchia, Carlo ;

Vatten, Lars ;

Gavin, Anna ;

Hery, Clarisse ;

Heanue, Mary .

BMJ-BRITISH MEDICAL JOURNAL, 2010, 341 :335

[5] Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA) [J].

Biganzoli, Laura ;

Wildiers, Hans ;

Oakman, Catherine ;

Marotti, Lorenza ;

Loibl, Sibylle ;

Kunkler, Ian ;

Reed, Malcolm ;

Ciatto, Stefano ;

Voogd, Adri C. ;

Brain, Etienne ;

Cutuli, Bruno ;

Terret, Catherine ;

Gosney, Margot ;

Aapro, Matti ;

Audisio, Riccardo .

LANCET ONCOLOGY, 2012, 13 (04) :E148-E160

[6] Undertreatment strongly decreases prognosis of breast cancer in elderly women [J].

Bouchardy, C ;

Rapiti, E ;

Fioretta, G ;

Laissue, P ;

Neyroud-Caspar, I ;

Schäfer, P ;

Kurtz, J ;

Sappino, AP ;

Vlastos, G .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (19) :3580-3587

[7] A NEW METHOD OF CLASSIFYING PROGNOSTIC CO-MORBIDITY IN LONGITUDINAL-STUDIES - DEVELOPMENT AND VALIDATION [J].

CHARLSON, ME ;

POMPEI, P ;

ALES, KL ;

MACKENZIE, CR .

JOURNAL OF CHRONIC DISEASES, 1987, 40 (05) :373-383

[8] Breast cancer in the elderly [J].

Crivellari, Diana ;

Aapro, Matti ;

Leonard, Robert ;

von Minckwitz, Gunter ;

Brain, Etienne ;

Goldhirsch, Aron ;

Veronesi, Andrea ;

Muss, Hyman .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (14) :1882-1890

[9] Effectiveness of adjuvant chemotherapy for node-positive operable breast cancer in older women [J].

Du, XLL ;

Jones, DV ;

Zhang, D .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2005, 60 (09) :1137-1144

[10] Population-based assessment of hospitalizations for toxicity from chemotherapy in older women with breast cancer [J].

Du, XLL ;

Osborne, C ;

Goodwin, JS .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (24) :4636-4642

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