Tocilizumab: A novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases

被引：59

作者：

Alten, Rieke ^{[1
]}

Maleitzke, Tazio ^{[1
]}

机构：

[1] Univ Med Berlin, Schlosspk Klin, D-10459 Berlin, Germany

来源：

ANNALS OF MEDICINE | 2013年 / 45卷 / 04期

关键词：

Interleukin-6; monoclonal receptor antibody; rare diseases; rheumatic diseases; rheumatoid arthritis; tocilizumab; GIANT-CELL ARTERITIS; SERONEGATIVE SYMMETRICAL SYNOVITIS; LARGE-VESSEL VASCULITIS; ONSET STILLS-DISEASE; ANKYLOSING-SPONDYLITIS; POLYMYALGIA-RHEUMATICA; TAKAYASU ARTERITIS; AA AMYLOIDOSIS; PITTING EDEMA; RELAPSING POLYCHONDRITIS;

D O I：

10.3109/07853890.2013.771986

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tocilizumab is a highly effective therapeutic agent for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis. Furthermore, a large amount of case study data reveals that tocilizumab can be an effective therapy for not only rheumatoid arthritis but also for other mostly rare inflammatory rheumatic diseases. By blocking the interleukin-6 pathway tocilizumab can be a useful therapeutic alternative when conventional treatment fails. It is successful in treating diseases such as the adult-onset Still's disease, amyloidosis, giant cell arteritis, multiple myeloma, polymyalgia rheumatica, relapsing polychondritis, remitting seronegative symmetrical synovitis with pitting edema-syndrome, systemic lupus erythematosus, systemic sclerosis, and Takayasu arteritis. Studies underway are now recruiting patients to acquire further data on treating patients with non-rheumatic arthritis, inflammatory diseases. This review focuses on tocilizumab as a promising agent for treating rare and orphan diseases in rheumatology for which no satisfactory treatment is yet available.

引用

页码：357 / 363

页数：7

共 48 条

[1] Tocilizumab: a novel humanized anti-interleukin 6 receptor antibody for the treatment of patients with rheumatoid arthritis [J].

Alten, Rieke .

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2011, 3 (03) :133-149

[2]

AREND WP, 1990, ARTHRITIS RHEUM, V33, P1129

[3] Ankylosing spondylitis [J].

Braun, Juergen ;

Sieper, Joachim .

LANCET, 2007, 369 (9570) :1379-1390

[4] Tocilizumab in a patient with ankylosing spondylitis and Crohn's disease refractory to TNF antagonists [J].

Brulhart, Laure ;

Nissen, Michael J. ;

Chevallier, Paola ;

Gabay, Cem .

JOINT BONE SPINE, 2010, 77 (06) :625-626

[5]

Chen DY, 2004, J RHEUMATOL, V31, P2189

[6] Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis [J].

Cutolo, M. ;

Montecucco, C. M. ;

Cavagna, L. ;

Caporali, R. ;

Capellino, S. ;

Montagna, P. ;

Fazzuoli, L. ;

Villaggio, B. ;

Seriolo, B. ;

Sulli, A. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (11) :1438-1443

[7]

De Benedetti F., 2013, ANN RHEUM DIS, V71, P425

[8] Diagnosis and management of adult onset Still's disease [J].

Efthimiou, P ;

Paik, PK ;

Bielory, L .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (05) :564-572

[9] American College of Rheumatology/European League Against Rheumatism Provisional Definition of Remission in Rheumatoid Arthritis for Clinical Trials [J].

Felson, David T. ;

Smolen, Josef S. ;

Wells, George ;

Zhang, Bin ;

van Tuyl, Lilian H. D. ;

Funovits, Julia ;

Aletaha, Daniel ;

Allaart, Cornelia F. ;

Bathon, Joan ;

Bombardieri, Stefano ;

Brooks, Peter ;

Brown, Andrew ;

Matucci-Cerinic, Marco ;

Choi, Hyon ;

Combe, Bernard ;

de Wit, Maarten ;

Dougados, Maxime ;

Emery, Paul ;

Furst, Daniel ;

Gomez-Reino, Juan ;

Hawker, Gillian ;

Keystone, Edward ;

Khanna, Dinesh ;

Kirwan, John ;

Kvien, Tore K. ;

Landewe, Robert ;

Listing, Joachim ;

Michaud, Kaleb ;

Martin-Mola, Emilio ;

Montie, Pamela ;

Pincus, Theodore ;

Richards, Pamela ;

Siegel, Jeffrey N. ;

Simon, Lee S. ;

Sokka, Tuulikki ;

Strand, Vibeke ;

Tugwell, Peter ;

Tyndall, Alan ;

van der Heijde, Desiree ;

Verstappen, Suzan ;

White, Barbara ;

Wolfe, Frederick ;

Zink, Angela ;

Boers, Maarten .

ARTHRITIS AND RHEUMATISM, 2011, 63 (03) :573-586

[10] Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis:: detection of tumour necrosis factor α in two patients with early disease and transforming growth factor β in three more advanced cases [J].

Francois, R. J. ;

Neure, L. ;

Sieper, J. ;

Braun, J. .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (06) :713-720

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