Historical Lessons in Translational Medicine Cyclooxygenase Inhibition and P2Y12 Antagonism

被引：32
|
作者：
Fitzgerald, Desmond J. [2 ]
FitzGerald, Garret A. [1 ]
机构：
[1] Univ Penn, Inst Translat Med & Therapeut, Translat Res Ctr, Philadelphia, PA 19104 USA
[2] Univ Coll Dublin, Dublin, Ireland
来源：
CIRCULATION RESEARCH | 2013年 / 112卷 / 01期
基金：
美国国家卫生研究院;
关键词：
aspirin; platelet; prostaglandin; PERCUTANEOUS CORONARY INTERVENTION; LOW-DOSE ASPIRIN; INDUCED PLATELET-AGGREGATION; ACUTE MYOCARDIAL-INFARCTION; GENE SEQUENCE VARIATIONS; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE; ADVERSE CARDIOVASCULAR EVENTS; THROMBOXANE BIOSYNTHESIS; ANTIPLATELET THERAPY; UNSTABLE ANGINA;
D O I：
10.1161/CIRCRESAHA.111.300271
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The development of drugs that inhibit platelets has been driven by a combination of clinical insights, fundamental science, and sheer luck. The process has evolved as the days of stumbling on therapeutic gems, such as aspirin, have long passed and have been replaced by an arduous process in which a drug is designed to target a specific protein implicated in a well-characterized pathophysiological process, or so we would like to believe. The development of antiplatelet therapy illustrates the importance of understanding the mechanisms of disease and the pharmacology of the compounds we develop, coupled with careful clinical experimentation and observation and, yes, still, a fair bit of luck. (Circ Res. 2013; 112: 174-194.)
引用
收藏
页码：174 / 194
页数：21
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