Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation

被引：29

作者：

Bozzetto, Lutgarda ^{[1
]}

Costabile, Giuseppina ^{[1
]}

Luongo, Delia ^{[2
]}

Naviglio, Daniele ^{[3
]}

Cicala, Valentina ^{[1
]}

Piantadosi, Chiara ^{[1
]}

Patti, Lidia ^{[1
]}

Cipriano, Paola ^{[1
]}

Annuzzi, Giovanni ^{[1
]}

Rivellese, Angela A. ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy

[2] CNR, Inst Biostruct & Bioimaging, Naples, Italy

[3] Univ Naples Federico II, Dept Chem Sci, Naples, Italy

来源：

DIABETOLOGIA | 2016年 / 59卷 / 12期

关键词：

De novo lipogenesis; Diet; Liver fat; Monounsaturated fatty acids; Stearoyl-coenzyme A desaturase-1 activity; Type; 2; Diabetes; beta-Hydroxybutyrate; beta-Oxidation; PLASMA;

D O I：

10.1007/s00125-016-4110-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this work was to investigate hepatic lipid metabolic processes possibly involved in the reduction of liver fat content (LF) observed in patients with type 2 diabetes after an isoenergetic diet enriched in monounsaturated fatty acids (MUFAs). This is an ancillary analysis of a published study. In a parallel-group design, 30 men and eight women, aged 35-70 years, with type 2 diabetes and whose blood glucose was controlled satisfactorily (HbA(1c) < 7.5% [58 mmol/mol]) by diet or diet plus metformin, were randomised by MINIM software to follow either a high-carbohydrate/high-fibre/low-glycaemic index diet (CHO/fibre diet, n = 20) or a high-MUFA diet (MUFA diet, n = 18) for 8 weeks. The assigned diets were known for the participants and blinded for people doing measurements. Before and after intervention, LF was measured by H-1-MRS (primary outcome) and indirect indices of de novo lipogenesis (DNL) (serum triacylglycerol palmitic:linoleic acid ratio), stearoyl-CoA desaturase activity (SCD-1) (serum triacylglycerol palmitoleic:palmitic acid ratio) and hepatic beta-oxidation of fatty acids (beta-hydroxybutyrate plasma concentrations) were measured. LF was reduced by 30% after the MUFA diet, as already reported. Postprandial beta-hydroxybutyrate incremental AUC (iAUC) was significantly less suppressed after the MUFA diet (n = 16) (-2504 +/- 4488 mu mol/l x 360 min vs baseline -9021 +/- 6489 mu mol/l x 360 min) while it was unchanged after the CHO/fibre diet (n = 17) (-8168 +/- 9827 mu mol/l x 360 min vs baseline -7206 +/- 10,005 mu mol/l x 360 min, p = 0.962) (mean +/- SD, p = 0.043). In the participants assigned to the MUFA diet, the change in postprandial beta-hydroxybutyrate iAUC was inversely associated with the change in LF (r = -0.642, p = 0.010). DNL and SCD-1 indirect indices did not change significantly after either of the dietary interventions. Postprandial hepatic oxidation of fatty acids is a metabolic process possibly involved in the reduction of LF by a MUFA-rich diet in patients with type 2 diabetes.

引用

页码：2697 / 2701

页数：5

共 12 条

[11] Hepatic Lipid Composition and Stearoyl-Coenzyme A Desaturase 1 mRNA Expression Can Be Estimated from Plasma VLDL Fatty Acid Ratios [J].