Direct observations of the metal-ligand bifunctional addition step in an enantioselective ketone hydrogenation

被引：92

作者：

Hamilton, Robin J. ^{[1
]}

Bergens, Steven H. ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 36期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ja8034812

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic intermediate trans-[Ru((R)-BINAP)(H)(2)((R,R)-dpen)] (1) reacted on mixing with acetophenone in THF at -80 degrees C under similar to 2 atm H-2 to generate the alkoxide trans-Ru((R)-BINAP)(H)-((Ph)(Me)CHO)((R,R)-dpen) (6). Contrary to expectations, free Ru-amide and 1-phenylethanol were not the immediate products of this addition reaction. The addition reaction was reversible in THF. 2-Propanol prevents racemization of the alcohol product in THF solvent.

引用

页码：11979 / 11987

页数：9

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