State estimation for a model of gene expression

被引：3

作者：

Lillacci, Gabriele ^{[1
]}

Valigi, Paolo ^{[2
]}

机构：

[1] Univ Perugia, Dipartimento Ingn Elettron & Informaz, Via G Duranti 93, I-06125 Perugia, Italy

[2] Univ Perugia, Polo Sci Didattico Teri, I-05100 Temi, Italy

来源：

PROCEEDINGS OF 2008 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS, VOLS 1-10 | 2008年

关键词：

D O I：

10.1109/ISCAS.2008.4541850

中图分类号：

TP3 [计算技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper we study the state estimation problem for a basic model of gene expression. The model describes the interaction between mRNA and protein(s) within the transcription-translation process. We first study some basic dynamic properties of the model, namely the existence of a unique equilibrium point, its stability and local observability. Then, we address the problem of estimating mRNA concentration by only measuring total protein concentration, and we propose a solution to it by means of different state estimation schemes. Finally, by means of in silico experiments, we compare the performance of the proposed structures.

引用

页码：2046 / +

页数：2

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