The diversity and disparity of the glial scar

被引：294

作者：

Adams, Katrina L. ^{[1
]}

Gallo, Vittorio ^{[1
]}

机构：

[1] Childrens Natl Med Ctr, Ctr Neurosci Res, Washington, DC 20010 USA

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 01期

关键词：

SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; CHONDROITIN SULFATE PROTEOGLYCANS; OLIGODENDROCYTE PRECURSOR CELLS; NEURAL STEM-CELLS; REACTIVE ASTROCYTES; NG2; PROTEOGLYCAN; CNS INJURY; NG2-POSITIVE CELLS; MACROPHAGE SUBSETS;

D O I：

10.1038/s41593-017-0033-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Injury or disease to the CNS results in multifaceted cellular and molecular responses. One such response, the glial scar, is a structural formation of reactive glia around an area of severe tissue damage. While traditionally viewed as a barrier to axon regeneration, beneficial functions of the glial scar have also been recently identified. In this Perspective, we discuss the divergent roles of the glial scar during CNS regeneration and explore the possibility that these disparities are due to functional heterogeneity within the cells of the glial scar-specifically, astrocytes, NG2 glia and microglia.

引用

页码：9 / 15

页数：7

共 81 条

[1] Extensive cortical remyelination in patients with chronic multiple sclerosis [J].

Albert, Monika ;

Antel, Jack ;

Brueck, Wolfgang ;

Stadelmann, Christine .

BRAIN PATHOLOGY, 2007, 17 (02) :129-138

[2] Astrocyte scar formation aids central nervous system axon regeneration [J].

Anderson, Mark A. ;

Burda, Joshua E. ;

Ren, Yilong ;

Ao, Yan ;

O'Shea, Timothy M. ;

Kawaguchi, Riki ;

Coppola, Giovanni ;

Khakh, Baljit S. ;

Deming, Timothy J. ;

Sofroniew, Michael V. .

NATURE, 2016, 532 (7598) :195-+

[3] Heterogeneity of reactive astrocytes [J].

Anderson, Mark A. ;

Ao, Yan ;

Sofroniew, Michael V. .

NEUROSCIENCE LETTERS, 2014, 565 :23-29

[4] Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury [J].

Assinck, Peggy ;

Duncan, Greg J. ;

Plemel, Jason R. ;

Lee, Michael J. ;

Stratton, Jo A. ;

Manesh, Sohrab B. ;

Liu, Jie ;

Ramer, Leanne M. ;

Kang, Shin H. ;

Bergles, Dwight E. ;

Biernaskie, Jeff ;

Tetzlaff, Wolfram .

JOURNAL OF NEUROSCIENCE, 2017, 37 (36) :8635-8654

[5] Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation [J].

Bardehle, Sophia ;

Krueger, Martin ;

Buggenthin, Felix ;

Schwausch, Julia ;

Ninkovic, Jovica ;

Clevers, Hans ;

Snippert, Hugo J. ;

Theis, Fabian J. ;

Meyer-Luehmann, Melanie ;

Bechmann, Ingo ;

Dimou, Leda ;

Goetz, Magdalena .

NATURE NEUROSCIENCE, 2013, 16 (05) :580-+

[6]

Ben Haim L, 2017, NAT REV NEUROSCI, V18, P31, DOI [10.1038/nm.2016.159, 10.1038/nrn.2016.159]

[7] New tools for studying microglia in the mouse and human CNS [J].

Bennett, Mariko L. ;

Bennett, F. Chris ;

Liddelow, Shane A. ;

Ajami, Bahareh ;

Zamanian, Jennifer L. ;

Fernhoff, Nathaniel B. ;

Mulinyawe, Sara B. ;

Bohlen, Christopher J. ;

Adil, Aykezar ;

Tucker, Andrew ;

Weissman, Irving L. ;

Chang, Edward F. ;

Li, Gordon ;

Grant, Gerald A. ;

Gephart, Melanie G. Hayden ;

Barres, Ben A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (12) :E1738-E1746

[8] Neuron-glia synapses in the brain [J].

Bergles, Dwight E. ;

Jabs, Ronald ;

Steinhaeuser, Christian .

BRAIN RESEARCH REVIEWS, 2010, 63 (1-2) :130-137

[9] Chondroitinase ABC promotes functional recovery after spinal cord injury [J].

Bradbury, EJ ;

Moon, LDF ;

Popat, RJ ;

King, VR ;

Bennett, GS ;

Patel, PN ;

Fawcett, JW ;

McMahon, SB .

NATURE, 2002, 416 (6881) :636-640

[10] Origin and progeny of reactive gliosis:: A source of multipotent cells in the injured brain [J].

Buffo, Annalisa ;

Rite, Inmaculada ;

Tripathi, Pratibha ;

Lepier, Alexandra ;

Colak, Dilek ;

Horn, Ana-Paula ;

Mori, Tetsuji ;

Goetz, Magdalena .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3581-3586

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