Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

被引：450

作者：

Lennon, Anne Marie ^{[1
,2
,3
]}

Buchanan, Adam H. ^{[4
]}

Kinde, Isaac ^{[5
]}

Warren, Andrew ^{[5
,6
]}

Honushefsky, Ashley ^{[4
]}

Cohain, Ariella T. ^{[5
]}

Ledbetter, David H. ^{[4
]}

Sanfilippo, Fred ^{[7
]}

Sheridan, Kathleen ^{[4
]}

Rosica, Dillenia ^{[4
]}

Adonizio, Christian S. ^{[4
,8
]}

Hwang, Hee Jung ^{[5
]}

Lahouel, Kamel ^{[1
,9
]}

Cohen, Joshua D. ^{[1
,2
,10
,11
,12
]}

Douville, Christopher ^{[1
,11
]}

Patel, Aalpen A. ^{[4
]}

Hagmann, Leonardo N. ^{[5
]}

Rolston, David D. ^{[4
]}

Malani, Nirav ^{[5
]}

Zhou, Shibin ^{[1
,11
]}

Bettegowda, Chetan ^{[1
,11
,13
]}

Diehl, David L. ^{[4
]}

Urban, Bobbi ^{[5
]}

Still, Christopher D. ^{[4
]}

Kann, Lisa ^{[5
]}

Woods, Julie I. ^{[4
]}

Salvati, Zachary M. ^{[4
]}

Vadakara, Joseph ^{[4
]}

Leeming, Rosemary ^{[4
]}

Bhattacharya, Prianka ^{[4
]}

Walter, Carroll ^{[4
]}

Parker, Alex ^{[5
]}

Lengauer, Christoph ^{[5
,6
]}

Klein, Alison ^{[1
,2
,14
]}

Tomasetti, Cristian ^{[1
,9
,15
]}

Fishman, Elliot K. ^{[1
,2
,16
]}

Hruban, Ralph H. ^{[1
,2
,17
]}

Kinzler, Kenneth W. ^{[1
,2
,11
]}

Vogelstein, Bert ^{[1
,2
,10
,11
]}

Papadopoulos, Nickolas ^{[1
,2
,11
,17
]}

机构：

[1] Johns Hopkins Univ, Dept Oncol, Sidney Kimmel Canc Ctr, Sch Med, 733 N Broadway, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Sol Goldman Pancreat Canc Res Ctr, 733 N Broadway, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, 733 N Broadway, Baltimore, MD 21205 USA

[4] Geisinger, 100 N Acad Ave, Danville, PA 17822 USA

[5] Thrive Earlier Detect Corp, 38 Sidney St, Cambridge, MA 02139 USA

[6] Third Rock Ventures LLC, 29 Newbury St, Boston, MA 02116 USA

[7] Emory Univ, Sch Med, Dept Pathol & Lab Med, 100 Woodruff Circle, Atlanta, GA 30322 USA

[8] Geisinger Canc Inst, 100 N Acad Ave, Danville, PA 17822 USA

[9] Johns Hopkins Univ, Dept Oncol, Sch Med, Div Biostat & Bioinformat, 733 N Broadway, Baltimore, MD 21205 USA

[10] Johns Hopkins Univ, Howard Hughes Med Inst, Sch Med, 733 N Broadway, Baltimore, MD 21205 USA

[11] Johns Hopkins Univ, Ludwig Ctr, Sch Med, 733 N Broadway, Baltimore, MD 21205 USA

[12] Johns Hopkins Univ, Dept Biomed Engn, Sch Med, 733 N Broadway, Baltimore, MD 21205 USA

[13] Johns Hopkins Univ, Dept Neurosurg, Sch Med, 733 N Broadway, Baltimore, MD 21205 USA

[14] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 615 N Wolfe St, Baltimore, MD 21205 USA

[15] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, 615 N Wolfe St, Baltimore, MD 21205 USA

[16] Johns Hopkins Univ, Sch Med, Dept Radiol, 733 N Broadway, Baltimore, MD 21205 USA

[17] Johns Hopkins Univ, Sch Med, Dept Pathol, 733 N Broadway, Baltimore, MD 21205 USA

来源：

SCIENCE | 2020年 / 369卷 / 6499期

基金：

美国国家卫生研究院;

关键词：

DNA; PLASMA; QUANTIFICATION; STRATEGIES; MUTATIONS; DIAGNOSIS;

D O I：

10.1126/science.abb9601

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomographycomputed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.

引用

页码：49 / +

页数：40

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