Probable Congenital Transmission of Reticuloendotheliosis Virus Caused by Vaccination with Contaminated Vaccines

被引:36
作者
Wei, Kai [1 ]
Sun, Zhenhong [1 ]
Zhu, Shufen [1 ]
Guo, Wenlong [1 ]
Sheng, Pengcheng [1 ]
Wang, Zunmin [1 ]
Zhao, Changliang [1 ]
Zhao, Qingyou [1 ]
Zhu, Ruiliang [1 ]
机构
[1] Shandong Agr Univ, Coll Anim Sci & Technol, Key Lab Biol Prod, Tai An, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
AVIAN-LEUKOSIS-VIRUS; VERTICAL TRANSMISSION; SUBGROUP J; CHICKENS; INFECTION; GENOME; STRAIN;
D O I
10.1371/journal.pone.0043422
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines. Furthermore, the REV was probably transmitted to the commercial chickens through congenital transmission.
引用
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页数:7
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