DHEA and DHEA-S response to acute psychosocial stress in healthy men and women

被引：124
作者：
Lennartsson, Anna-Karin [1 ,2 ]
Kushnir, Mark M. [3 ,4 ,5 ]
Bergquist, Jonas [3 ,5 ]
Jonsdottir, Ingibjorg H. [1 ,2 ]
机构：
[1] Inst Stress Med, S-41319 Gothenburg, Sweden
[2] Univ Gothenburg, Sahlgrenska Acad, Dept Neurosci & Physiol, Gothenburg, Sweden
[3] Uppsala Univ, Dept Analyt Chem, Uppsala, Sweden
[4] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA
[5] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA
来源：
BIOLOGICAL PSYCHOLOGY | 2012年 / 90卷 / 02期
基金：
瑞典研究理事会;
关键词：
DHEA; DHEA-S; Acute stress; Trier Social Stress Test; Men and women; MASS-SPECTROMETRY ASSAY; PITUITARY-ADRENAL AXIS; AGE-RELATED-CHANGES; DEHYDROEPIANDROSTERONE-SULFATE; SEX-DIFFERENCES; SERUM; CORTISOL; ADRENOCORTICOTROPIN; TESTOSTERONE; PERFORMANCE;
D O I：
10.1016/j.biopsycho.2012.03.003
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
This study investigates the effect of acute psychosocial stress on serum concentrations of DHEA and DHEA-S in healthy men and women. Twenty men and 19 women (age 30-50 years) underwent Trier Social Stress Test (TSST). Physiological measurements were performed before, directly after the stress test and after 30 mins of recovery. In both men and women, significantly elevated DHEA and DHEA-S levels were observed in response to the stressor. There was a large inter-individual variation in the magnitude of the response, especially for DHEA but no statistical difference between men and women. Magnitude of the change in the levels of DHEA was found to be positively associated with the magnitude of the changes in ACTH, cortisol and heart rate. Furthermore, the results of this study suggest that the capacity to secrete DHEA and DHEA-S during acute psychosocial stress declines with age. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：143 / 149
页数：7
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