Immune microenvironment in Barrett's esophagus adjacent to esophageal adenocarcinoma: possible influence of adjacent mucosa on cancer development and progression

被引：10

作者：

Gokon, Yusuke ^{[1
,2
]}

Fujishima, Fumiyoshi ^{[2
]}

Taniyama, Yusuke ^{[1
]}

Ishida, Hirotaka ^{[1
]}

Yamagata, Taku ^{[3
]}

Sawai, Takashi ^{[4
]}

Uzuki, Miwa ^{[5
]}

Ichikawa, Hirofumi ^{[6
]}

Itakura, Yuko ^{[7
]}

Takahashi, Kazutomi ^{[8
]}

Yajima, Nobuhisa ^{[9
]}

Hagiwara, Motohisa ^{[10
]}

Nishida, Akiko ^{[11
]}

Ozawa, Yohei ^{[12
]}

Sakuma, Tsutomu ^{[13
]}

Kanba, Rikiya ^{[14
]}

Sakamoto, Kazuhiro ^{[15
]}

Zuguchi, Masashi ^{[16
]}

Saito, Masahiro ^{[17
]}

Kamei, Takashi ^{[1
]}

Sasano, Hironobu ^{[2
]}

机构：

[1] Tohoku Univ Hosp, Dept Surg, Sendai, Miyagi, Japan

[2] Tohoku Univ Hosp, Dept Pathol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan

[3] Sendai City Med Ctr, Dept Gastroenterol, Sendai, Miyagi, Japan

[4] Sendai City Med Ctr, Dept Pathol, Sendai, Miyagi, Japan

[5] Tohoku Bunka Gakuen Univ, Dept Med Sci & Welf, Sendai, Miyagi, Japan

[6] Japanese Red Cross Ishinomaki Hosp, Dept Surg, Ishinomaki, Japan

[7] Japanese Red Cross Ishinomaki Hosp, Dept Pathol, Ishinomaki, Japan

[8] Hachinohe Municipal Hosp, Dept Surg, Hachinohe, Aomori, Japan

[9] Hachinohe Municipal Hosp, Dept Pathol & Lab Med, Hachinohe, Aomori, Japan

[10] Nihonkai Gen Hosp, Dept Surg, Sakata, Yamagata, Japan

[11] Nihonkai Gen Hosp, Dept Pathol, Sakata, Yamagata, Japan

[12] Iwate Prefectural Cent Hosp, Dept Gastrointestinal Surg, Morioka, Iwate, Japan

[13] Iwate Prefectural Cent Hosp, Dept Pathol, Morioka, Iwate, Japan

[14] Osaki Citizen Hosp, Dept Surg, Saki, Japan

[15] Osaki Citizen Hosp, Dept Pathol, Osaki, Japan

[16] Hiraka Gen Hosp, Dept Surg, Yokote, Japan

[17] Hiraka Gen Hosp, Dept Pathol, Yokote, Japan

来源：

VIRCHOWS ARCHIV | 2020年 / 477卷 / 06期

关键词：

Esophageal adenocarcinoma; Barrett's esophagus; Adjacent mucosa; Microenvironment; Immunohistochemistry; Lymphocyte; REGULATORY T-CELLS; NEOPLASTIC PROGRESSION; IMPROVED SURVIVAL; PROGNOSTIC-FACTOR; RISK; P53; ASSOCIATION; EXPRESSION; DYSPLASIA; DIAGNOSIS;

D O I：

10.1007/s00428-020-02854-0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The immune microenvironment plays a pivotal role in cancer development and progression. Therefore, we studied the status of immune cells in esophageal adenocarcinoma (EAC) and adjacent Barrett's esophagus (BE) and their association with the clinical course of patients. We included 87 patients with EAC who underwent surgical resection or endoscopic submucosal dissection. CD3, CD8, Foxp3, p53, and Ki-67 were immunolocalized in EAC and adjacent BE (N = 87) and BE without EAC (N = 13). BE adjacent to EAC exhibited higher CD3+ lamina propria lymphocyte (LPL) numbers than BE without EAC. Abundant Foxp3+ LPLs in BE were associated with dysplasia and increased Ki-67 labeling index (LI) in BE glandular cells and tended to link to aberrant p53 expression. Abundant CD8+ LPLs in adjacent BE were associated with worse prognosis of EAC patients (P = 0.019). Results of our present study firstly revealed the potential influence of the tissue immune microenvironment of BE adjacent to EAC on cancer development and eventual clinical outcome of EAC patients. T cell infiltration could play pivotal roles in facilitating the dysplasia-adenocarcinoma sequence in BE. The number of Foxp3+ T cells is increased at the early stage of carcinogenesis and could help identify patients harboring dysplastic and highly proliferating cells. CD8+ T cells could reflect unfavorable inflammatory response in adjacent tissue microenvironment and help predict worse prognosis of EAC patients.

引用

页码：825 / 834

页数：10

共 40 条

[11]

Japanese Classification of Esophageal Cancer, 2017, Esophagus : Official J Japan Esophageal Soc, V14, P1, DOI [10.1007/s10388-016-0551-7, DOI 10.1007/S10388-016-0551-7, DOI 10.1007/s10388-016-0551-7]

[12] Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus [J].