[1] Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England
[3] Genentech Inc, San Francisco, CA 94080 USA
[4] Kings Coll London, London WC2R 2LS, England
[5] Univ Sunderland, Sunderland SR2 7EE, Durham, England