PIK3CA mutations in human solid tumors Role in sensitivity to various therapeutic approaches

被引：174

作者：

Ligresti, Giovanni ^{[1
]}

Militello, Loredana ^{[1
]}

Steelman, Linda S. ^{[2
,3
]}

Cavallaro, Andrea ^{[1
]}

Basile, Francesco

Nicoletti, Ferdinando ^{[1
]}

Stivala, Franca ^{[1
]}

McCubrey, James A. ^{[2
,3
]}

Libra, Massimo ^{[1
]}

机构：

[1] Univ Catania, Dept Biomed Sci, I-95124 Catania, Italy

[2] Univ Catania, Dept Surg, I-95124 Catania, Italy

[3] E Carolina Univ, Brody Sch Med, Dept Microbiol & Immunol, Greenville, NC USA

来源：

CELL CYCLE | 2009年 / 8卷 / 09期

关键词：

PIK3CA; gene mutations; PI3K pathway; AKT; cancer; TRASTUZUMAB RESISTANCE; HIGH-FREQUENCY; PTEN FUNCTION; HUMAN CANCER; 3-KINASE; GENE; MECHANISM; OVARIAN; GROWTH; CELLS;

D O I：

10.4161/cc.8.9.8255

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110a subunit of PI3K (PIK3CA) have been identified in a broad spectrum of tumors. Analyses of PIK3CA mutations reveals that they increase the PI3K signal, stimulate downstream Akt signaling, promote growth factor-independent growth and increase cell invasion and metastasis. In this review, we analyze the contribution of the PIK3CA mutations in cancer, and their possible implications for diagnosis and therapy.

引用

页码：1352 / 1358

页数：7

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