HLA Class II (DRB, DQA1 and DQB1) Allele and Haplotype Frequencies in the Patients with Pemphigus Vulgaris

被引：52
|
作者：
Shams, Sheida [2 ]
Amirzargar, Ali Akbar [1 ,3 ]
Yousefi, Maryam [2 ]
Rezaei, Nima [4 ]
Solgi, Ghasem [1 ]
Khosravi, Farideh [1 ]
Ansaripour, Bita [1 ]
Moradi, Batoul [1 ]
Nikbin, Behrouz [1 ,3 ]
机构：
[1] Univ Tehran Med Sci, Sch Med, Dept Immunol, Immunogenet Lab, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Med, Razi Hosp, Dept Dermatol, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Med, Mol Immunol Res Ctr, Tehran, Iran
[4] Univ Tehran Med Sci, Immunol Asthma & Allergy Res Inst, Tehran, Iran
来源：
JOURNAL OF CLINICAL IMMUNOLOGY | 2009年 / 29卷 / 02期
关键词：
Allele frequency; haplotype frequency; human leukocyte antigen; pemphigus vulgaris; MAJOR HISTOCOMPATIBILITY COMPLEX; JEWISH PATIENTS; MICROSATELLITE MARKERS; ANCESTRAL ORIGIN; CELL RESPONSES; SUSCEPTIBILITY; ASSOCIATION; GENES; AUTOIMMUNITY; DESMOGLEIN-3;
D O I：
10.1007/s10875-008-9244-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pemphigus vulgaris (PV), an autoimmune disease affecting the skin and mucous membranes, is associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes in Iranian non-Jewish patients with PV, 52 patients with PV and 180 normal subjects as control group were investigated in this study. HLA-DRB1*04, -DRB1*1401, -DRB4, -DQA1*0104, -DQA1*03011, -DQB1*0302, and -DQB1*0502 alleles have been significantly increased in our patients group. Moreover, the haplotypes HLA-DRB1*04/-DQA1*03011/-DQB1*0302 and HLA-DRB1*1401/-DQA1*0104/-DQB1*0502 increased significantly in our patients. In contrast, the following alleles decreased significantly in our patients: HLA-DRB1*15, -DRB1*0301, -DRB1*07, -DRB1*11, -DRB5, -DQA1*0101, -DQA1*0103, -DQA1*201, -DQA1*05, -DQB1*0201, -DQB1*0301, -DQB1*06011, and -DQB1*0602. In addition, HLA-DRB1*15/-DQA1*0103/-DQB1*06011, HLA-DRB1*0301/-DQA1*05011/-DQB1*0201, HLA-DRB1*07/-DQA1*0201/-DQB1*0201, and HLA-DRB1*11/-DQA1*05/-DQB1*03011 decreased significantly in our patients. Genetic factors are involved in the occurrence of PV; HLA-DRB1*04 and -DRB1*1401 alleles and the related haplotypes are suggestive to be two major PV susceptibility factors in our population study.
引用
收藏
页码：175 / 179
页数：5
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