Synthesis of Quinazolines and Tetrahydroquinazolines: Copper-Catalyzed Tandem Reactions of 2-Bromobenzyl Bromides with Aldehydes and Aqueous Ammonia or Amines

被引：43

作者：

Fan, Xuesen ^{[1
]}

Li, Bin ^{[1
]}

Guo, Shenghai ^{[1
]}

Wang, Yuanyuan ^{[1
]}

Zhang, Xinying ^{[1
]}

机构：

[1] Henan Normal Univ, Key Lab Green Chem Media & React, Sch Chem & Chem Engn,Minist Educ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Xinxiang 453007, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 03期

关键词：

2-bromobenzyl bromides; CH functionalization; copper; heterocycles; 1; 2; 3; 4-tetrahydroquinazolines; COUPLING REACTIONS; DERIVATIVES; INHIBITORS; ROUTE;

D O I：

10.1002/asia.201301296

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of diversely substituted quinazolines and 1,2,3,4-tetrahydroquinazolines through copper-catalyzed tandem reactions of the readily available 2-bromobenzyl bromides, aldehydes, and aqueous ammonia or amines has been developed. By using ammonia and simple aliphatic amines as the nitrogen source, the present method provides a versatile and practical protocol for the synthesis of quinazolines and 1,2,3,4-tetrahydroquinazolines.

引用

页码：739 / 743

页数：5

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