Impaired theta phase-resetting underlying auditory N1 suppression in chronic alcoholism

被引：5

作者：

Fuentemilla, Lluis ^{[3
]}

Marco-Pallares, Josep ^{[4
]}

Gual, Antoni ^{[5
]}

Escera, Carles ^{[2
]}

Polo, Maria Dolores ^{[1
]}

Grau, Carles ^{[3
]}

机构：

[1] Burden Neurol Inst, Bristol BS16 1QT, Avon, England

[2] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Cognit Neurosci Res Grp, Barcelona, Spain

[3] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Neurodynam Lab, Barcelona, Spain

[4] Otto VonGuericke Univ Magdegurg, Inst Psychol 2, D-39016 Magdeburg, Germany

[5] IDIBAPS, Hosp Clin, Inst Neurosci, Alcohol Unit, Catalonia, Spain

来源：

NEUROREPORT | 2009年 / 20卷 / 03期

关键词：

alcoholism; auditory N1; gating; phase-resetting; theta; EVENT-RELATED RESPONSES; SENSORY MEMORY; NEUROMAGNETIC EVIDENCE; MISMATCH NEGATIVITY; DYNAMICS; OSCILLATIONS; BRAIN; INHIBITION; POTENTIALS; RECOVERY;

D O I：

10.1097/WNR.0b013e32832326ed

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that chronic alcoholism may lead to altered neural mechanisms related to inhibitory processes. Here, we studied auditory N1 suppression phenomena (i.e. amplitude reduction with repetitive stimuli) in chronic alcoholic patients as an early-stage information-processing brain function involving inhibition by the analysis of the N1 event-related potential and time-frequency computation (spectral power and phase-resetting). Our results showed enhanced neural 0 oscillatory phase-resetting underlying N1 generation in suppressed N1 event-related potential. The present findings suggest that chronic alcoholism alters neural oscillatory synchrony dynamics at very early stages of information processing. NeuroReport 20:337-342 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：337 / 342

页数：6

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