Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice

被引:39
作者
Abdel-Mageed, Aly S. [1 ]
Senagore, Anthony J. [1 ]
Pietryga, Daniel W. [1 ]
Connors, Robert H. [1 ]
Giambernardi, Troy A. [1 ]
Hay, Rick V. [1 ]
Deng, Weiwen [1 ]
机构
[1] Helen DeVos Childrens Hosp, Pediat Blood & Bone Marrow Transplantat Program, Grand Rapids, MI 49503 USA
关键词
GENE-THERAPY;
D O I
10.1182/blood-2008-07-170936
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1201 / 1203
页数:5
相关论文
共 10 条
[1]   Superoxide anion production in the rat penis impairs erectile function in diabetes: Influence of in vivo extracellular superoxide dismutase gene therapy [J].
Bivalacqua, TJ ;
Usta, MF ;
Kendirci, M ;
Pradhan, L ;
Alvarez, X ;
Champion, HC ;
Kadowitz, PJ ;
Hellstrom, WJG .
JOURNAL OF SEXUAL MEDICINE, 2005, 2 (02) :187-197
[2]   Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction [J].
Bivalacqua, Trinity J. ;
Deng, Weiwen ;
Kendirci, Muammer ;
Usta, Mustafa F. ;
Robinson, Christine ;
Taylor, Bradley K. ;
Murthy, Subramanyam N. ;
Champion, Hunter C. ;
Hellstrom, Wayne J. G. ;
Kadowitz, Philip J. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 292 (03) :H1278-H1290
[3]   Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome [J].
Chapel, A ;
Bertho, JM ;
Bensidhoum, M ;
Fouillard, L ;
Young, RG ;
Frick, J ;
Demarquay, C ;
Cuvelier, F ;
Mathieu, E ;
Trompier, F ;
Dudoignon, N ;
Germain, C ;
Mazurier, C ;
Aigueperse, J ;
Borneman, J ;
Gorin, NC ;
Gourmelon, P ;
Thierry, D .
JOURNAL OF GENE MEDICINE, 2003, 5 (12) :1028-1038
[4]   Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats - Role of heparin-binding domain [J].
Chu, Y ;
Iida, S ;
Lund, DD ;
Weiss, RM ;
DiBona, GF ;
Watanabe, Y ;
Faraci, FM ;
Heistad, DD .
CIRCULATION RESEARCH, 2003, 92 (04) :461-468
[5]   Nuclear terrorism: the role of hematology in coping with its health consequences [J].
Fliedner, Theodor M. .
CURRENT OPINION IN HEMATOLOGY, 2006, 13 (06) :436-444
[6]   Could gene therapy prevent the effects of irradiation exposure? [J].
Greenberger, J. S. .
PHARMACOGENOMICS, 2006, 7 (08) :1141-1145
[7]  
Greenberger J.S., 2005, PROGR GENE THERAPY, P110
[8]   AN EXPLANATION FOR THE ABILITY OF CYTO-TOXIC DRUG PRETREATMENT TO REDUCE BONE-MARROW RELATED LETHALITY OF TOTAL-BODY IRRADIATION (TBI) [J].
MILLAR, JL ;
STEPHENS, TC ;
WIST, EA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :581-583
[9]   Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential [J].
Peister, A ;
Mellad, JA ;
Larson, BL ;
Hall, BM ;
Gibson, LF ;
Prockop, DJ .
BLOOD, 2004, 103 (05) :1662-1668
[10]   Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method [J].
Sun, SK ;
Guo, ZK ;
Xiao, XR ;
Liu, B ;
Liu, XD ;
Tang, PH ;
Mao, N .
STEM CELLS, 2003, 21 (05) :527-535