Ropinirole for restless legs syndrome - A placebo-controlled crossover trial

被引：64

作者：

Adler, CH

Hauser, RA

Sethi, K

Caviness, JN

Marlor, L

Anderson, WM

Hentz, JG

机构：

[1] Mayo Clin Scottsdale, Dept Neurol, Parkinsons Dis & Movement Disorders Ctr, Scottsdale, AZ 85259 USA

[2] Mayo Clin Scottsdale, Dept Biostat, Scottsdale, AZ 85259 USA

[3] Univ S Florida, Dept Neurol, Tampa, FL 33620 USA

[4] Univ S Florida, Dept Pharmacol, Tampa, FL 33620 USA

[5] Univ S Florida, Dept Expt Therapeut, Tampa, FL 33620 USA

[6] Univ S Florida, Dept Internal Med, Tampa, FL 33620 USA

[7] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

来源：

NEUROLOGY | 2004年 / 62卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000120672.94060.F1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors performed a double-blind, placebo-controlled, crossover study of ropinirole (0.5 to 6.0 mg/day) for restless legs syndrome (RLS). The RLS Rating Scale score improved (p < 0.001) from a mean (SD) of 25 (7) during placebo treatment to 13 (12) during ropinirole treatment. Eight of the 22 patients had complete resolution of symptoms on ropinirole. Adverse events included nausea and dizziness. Ropinirole was effective and well tolerated for treating the symptoms of RLS.

引用

页码：1405 / 1407

页数：3

共 10 条

[1] Pergolide and carbidopa/levodopa treatment of the restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients [J].

Earley, CJ ;

Allen, RP .

SLEEP, 1996, 19 (10) :801-810

[2] Randomized, double-blind, placebo-controlled trial of pergolide in restless legs syndrome [J].

Earley, CJ ;

Yaffee, JB ;

Allen, RP .

NEUROLOGY, 1998, 51 (06) :1599-1602

[3] DOPAMINERGIC TREATMENT OF RESTLESS LEGS AND REBOUND PHENOMENON [J].

GUILLEMINAULT, C ;

CETEL, M ;

PHILIP, P .

NEUROLOGY, 1993, 43 (02) :445-445

[4] Restless legs syndrome improved by pramipexole - A double-blind randomized trial [J].

Montplaisir, J ;

Nicolas, A ;

Denesle, R ;

Gomez-Mancilla, B .

NEUROLOGY, 1999, 52 (05) :938-943

[5]

Ondo W, 1999, MOVEMENT DISORD, V14, P138, DOI 10.1002/1531-8257(199901)14:1<138::AID-MDS1023>3.3.CO

[6]

2-1

[7] Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole 1.: Findings on objective and subjective sleep and awakening quality [J].

Saletu, B ;

Gruber, G ;

Saletu, M ;

Brandstätter, N ;

Hauer, C ;

Prause, W ;

Ritter, K ;

Saletu-Zyhlarz, G .

NEUROPSYCHOBIOLOGY, 2000, 41 (04) :181-189

[8] Sleep laboratory studies in restless legs syndrome patients as compared with normals and acute effects of ropinirole 2. Findings on periodic leg movement, arousals and respiratory variables [J].

Saletu, M ;

Anderer, P ;

Saletu, B ;

Hauer, C ;

Mandl, M ;

Oberndorfer, S ;

Zoghlami, A ;

Saletu-Zyhlarz, G .

NEUROPSYCHOBIOLOGY, 2000, 41 (04) :190-199

[9] Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome [J].

Walters, AS ;

LeBrocq, C ;

Dhar, A ;

Hening, W ;

Rosen, R ;

Allen, RP ;

Trenkwalder, C ;

Adler, C ;

Newman, S ;

Reiners, C ;

Aksu, M ;

Allen, RP ;

Buchholz, D ;

Hening, WA ;

Anderson, M ;

Mosko, S ;

Ancoli-Israel, S ;

Jimenez, WB ;

Hallett, M ;

Bassetti, C ;

Clavadetscher, S ;

Bliwise, DL ;

Gurecki, P ;

Rye, DB ;

Broch, LL ;

Zak, R ;

Chokroverty, S ;

Coccagna, G ;

Lugaresi, E ;

Miele, F ;

Montagna, P ;

Plazzi, G ;

Provini, F ;

de Mello, MT ;

Tufik, S ;

de Weerd, AW ;

Rijsman, RM ;

Dhar, A ;

LeBrocq, C ;

Walters, AS ;

Ehrenberg, B ;

Eisensehr, I ;

Ekbom, K ;

Ljungdahl, A ;

Garcia-Borreguero, D ;

Larrosa, O ;

Hening, WA ;

Rosen, R ;

Walters, AS ;

Hening, WA .

SLEEP MEDICINE, 2003, 4 (02) :121-132

[10] TOWARD A BETTER DEFINITION OF THE RESTLESS LEGS SYNDROME [J].

WALTERS, AS .

MOVEMENT DISORDERS, 1995, 10 (05) :634-642

← 1 →