Type 1 diabetes management and outcomes: A multicenter study in Thailand

被引：17

作者：

Dejkhamron, Prapai ^{[1
,2
]}

Santiprabhob, Jeerunda ^{[3
,4
]}

Likitmaskul, Supawadee ^{[3
,4
]}

Deerochanawong, Chaicharn ^{[5
]}

Rawdaree, Petch ^{[6
]}

Tharavanij, Thipaporn ^{[7
,8
]}

Reutrakul, Sirimon ^{[9
]}

Kongkanka, Chawkaew ^{[10
]}

Suprasongsin, Chittiwat ^{[11
]}

Numbenjapon, Nawaporn ^{[12
]}

Sahakitrungruang, Taninee ^{[13
]}

Lertwattanarak, Raweewan ^{[3
,14
]}

Engkakul, Pontipa ^{[15
]}

Sriwijitkamol, Apiradee ^{[3
,14
]}

Korwutthikulrangsri, Manassawee ^{[16
]}

Leelawattana, Rattana ^{[17
]}

Phimphilai, Mattabhorn ^{[2
,18
]}

Potisat, Somkiat ^{[19
]}

Khananuraksa, Panthep ^{[20
]}

Nopmaneejumruslers, Cherdchai ^{[3
]}

Nitiyanant, Wannee ^{[3
,14
]}

机构：

[1] Chiang Mai Univ, Div Endocrinol & Metab, Dept Pediat, Fac Med, Chiang Mai, Thailand

[2] Chiang Mai Univ, Northern Diabet Ctr, Fac Med, Chiang Mai, Thailand

[3] Mahidol Univ, Fac Med, Siriraj Diabet Ctr, Siriraj Hosp, Bangkok, Thailand

[4] Mahidol Univ, Fac Med, Div Endocrinol & Metab, Dept Pediat,Siriraj Hosp, Bangkok, Thailand

[5] Rangsit Univ, Rajavithi Hosp, Div Endocrinol & Metab, Dept Med,Coll Med, Bangkok, Thailand

[6] Navamindradhiraj Univ, Vajira Hosp, Div Endocrinol & Metab, Dept Internal Med,Fac Med, Bangkok, Thailand

[7] Thammasat Univ, Dept Internal Med, Endocrine & Metab Unit, Fac Med, Pathum Thani, Thailand

[8] Thammasat Univ, Ctr Excellence Appl Epidemiol, Bangkok, Thailand

[9] Mahidol Univ, Fac Med, Div Endocrinol & Metab, Dept Med,Ramathibodi Hosp, Bangkok, Thailand

[10] Queen Sirikit Natl Inst Child Hlth, Dept Pediat, Endocrinol & Metab Unit, Bangkok, Thailand

[11] Mahidol Univ, Fac Med, Res Ctr, Ramathibodi Hosp, Bangkok, Thailand

[12] Phramongkutklao Hosp & Coll Med, Dept Pediat, Div Endocrinol Diabet & Metab, Bangkok, Thailand

[13] Chulalongkorn Univ, Dept Pediat, Div Pediat Endocrinol, Fac Med, Bangkok, Thailand

[14] Mahidol Univ, Fac Med, Dept Med, Div Endocrinol & Metab,Siriraj Hosp, Bangkok, Thailand

[15] Thammasat Univ, Dept Pediat, Endocrinol & Metab Unit, Fac Med, Pathum Thani, Thailand

[16] Mahidol Univ, Fac Med, Dept Pediat, Div Endocrinol & Metab,Ramathibodi Hosp, Bangkok, Thailand

[17] Prince Songkla Univ, Dept Med, Div Endocrinol & Metab, Fac Med, Hat Yai, Thailand

[18] Chiang Mai Univ, Dept Med, Div Endocrinol & Metab, Fac Med, Chiang Mai, Thailand

[19] Minist Publ Hlth, Dept Med Serv, Nonthaburi, Thailand

[20] Natl Hlth Secur Off, Bangkok, Thailand

来源：

JOURNAL OF DIABETES INVESTIGATION | 2021年 / 12卷 / 04期

关键词：

Intensive insulin treatment; Multiple daily insulin injection; Type 1 diabetes mellitus; METABOLIC-CONTROL; GLYCEMIC CONTROL; LIFE EXPECTANCY; BLOOD-GLUCOSE; CHILDREN; ADOLESCENTS; COMPLICATIONS; ASSOCIATION; FREQUENCY; SYMPTOMS;

D O I：

10.1111/jdi.13390

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/Introduction The Thai Type 1 Diabetes and Diabetes Diagnosed Before Age 30 Years Registry, Care and Network was established in 2014 and involved 31 hospitals. The objective of the registry was to evaluate glycemic control and complications of patients with type 1 diabetes. Materials and Methods Patients' demographics, clinical data, frequencies of daily self-monitoring of blood glucose (SMBG), glycemic control and complications were collected. Results Among the 1,907 type 1 diabetes patients, the mean age was 21.2 +/- 11.3 years. The mean glycated hemoglobin level was 9.35 +/- 2.41%, with significant variations among age groups (P < 0.001). Conventional insulin treatment and intensive insulin treatment were used in 43 and 57% of patients, respectively. Mean glycated hemoglobin levels were significantly higher in patients treated with conventional insulin treatment compared to those treated with intensive insulin treatment (9.63 +/- 2.34 vs 9.17 +/- 2.46%,P = 0.002). Compared to the conventional insulin treatment group, significantly more patients in the intensive insulin treatment group achieved good glycemic control (P < 0.001), and fewer had diabetic retinopathy (P = 0.031). The prevalence of microvascular complications increased significantly with age (P < 0.001). Multivariate analysis showed good glycemic control to be associated with age 25 to <45 years, intensive insulin treatment with SMBG three or more times daily and diabetes duration of 1 to <5 years. Conclusions Most Thai type 1 diabetes patients were not meeting the recommended glycemic target. As a result of this study, the national program to improve the quality of diabetes treatment and education has been implemented, and the results are ongoing.

引用

页码：516 / 526

页数：11

共 33 条

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