CURRENT CONCEPTS REVIEW Heterotopic Ossification: Basic-Science Principles and Clinical Correlates

被引：266

作者：

Ranganathan, Kavitha ^{[1
]}

Loder, Shawn ^{[1
]}

Agarwal, Shailesh ^{[1
]}

Wong, Victor W. ^{[2
]}

Forsberg, Jonathan ^{[3
]}

Davis, Thomas A. ^{[3
]}

Wang, Stewart ^{[1
]}

James, Aaron W. ^{[4
]}

Levi, Benjamin ^{[1
]}

机构：

[1] Univ Michigan Hlth Syst, Dept Surg, Taubman Ctr, Ann Arbor, MI 48109 USA

[2] Johns Hopkins Sch Med, Dept Surg, Baltimore, MD 21236 USA

[3] Naval Med Res Ctr, Dept Regenerat Med, Silver Spring, MD 20910 USA

[4] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 2015年 / 97A卷 / 13期

关键词：

NONSTEROIDAL ANTIINFLAMMATORY DRUGS; TOTAL HIP-REPLACEMENT; ACETABULAR FRACTURES; RADIATION-THERAPY; RANDOMIZED-TRIAL; PROGENITOR CELLS; BONE-FORMATION; TRAUMATIC BRAIN; RISK-FACTORS; PREVENTION;

D O I：

10.2106/JBJS.N.01056

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury. The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification. Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification. Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury. Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.

引用

页码：1101 / 1111

页数：11

共 110 条

[1] Risk factors for development of heterotopic ossification of the elbow after fracture fixation [J].