The effect of androgens on lipids

被引：36

作者：

Monroe, Anne K. ^{[1
]}

Dobs, Adrian S. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Div Gen Internal Med, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Div Endocrinol & Metab, Dept Med, Sch Med, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY | 2013年 / 20卷 / 02期

关键词：

cardiovascular disease; lipids; testosterone; ENDOGENOUS SEX-HORMONES; LOW SERUM TESTOSTERONE; MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; CHOLESTEROL EFFLUX; BINDING GLOBULIN; BODY-COMPOSITION; HYPOGONADAL MEN; RISK-FACTORS; MORTALITY;

D O I：

10.1097/MED.0b013e32835edb71

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids. Recent findings Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials. Summary There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone administration in hypogonadal men. The overall effect of testosterone on CVD risk has not been definitively determined.

引用

页码：132 / 139

页数：8

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