Discovery of the rare HLA-B*39:77 allele in an unrelated Taiwanese bone marrow stem cell donor using the sequence-based typing method

被引：0
作者：
Yang, K. L. [1 ,2 ,3 ,4 ]
Lee, S. K. [1 ,2 ,3 ]
Lin, P. Y. [1 ,2 ,3 ]
机构：
[1] Buddhist Compass Relief Tzu Chi Fdn, Immunogenet Lab, Buddhist Tzu Chi Gen Hosp, Hualien 970, Taiwan
[2] Buddhist Compass Relief Tzu Chi Fdn, Cord Blood Bank, Buddhist Tzu Chi Gen Hosp, Buddhist Tzu Chi Stem Cells Ctr, Hualien 970, Taiwan
[3] Buddhist Compass Relief Tzu Chi Fdn, Marrow Donor Registry, Buddhist Tzu Chi Gen Hosp, Hualien 970, Taiwan
[4] Buddhist Tzu Chi Univ, Buddhist Compass Relief Tzu Chi Fdn, Dept Med Biotechnol, Hualien, Taiwan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2013年 / 40卷 / 04期
关键词：
LEUKOCYTE ANTIGEN-A; HLA-B; HAPLOTYPES;
D O I：
10.1111/iji.12036
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We detected a rare HLA-B locus allele, B*39:77, in a Taiwanese unrelated marrow stem cell donor in our routine HLA sequence-based typing (SBT) exercise for a possible haematopoietic stem cell donation. In exons 2, 3 and 4, the DNA sequence of B*39:77 is identical to the sequence of B*39:01:01:01 except one nucleotide at nucleotide position 733 (G->A) in exon 4. The nucleotide variation caused one amino acid alteration at residue 221 (Gly->Ser). B*39:77 was probably derived from a nucleotide substitution event involving B*39:01:01:01. The probable HLA-A, -B, -C, -DRB1 and -DQB1 haplotype in association with B*39:77 may be deduced as A*02:01-B*39:77-C*07:02-DRB1*08:03-DQB1*06:01. Our discovery of B*39:77 in Taiwanese adds further polymorphism of B*39 variants in Taiwanese population.
引用
收藏
页码：331 / 334
页数：4
相关论文
共 10 条
[1]   Discovery of HLA-B*480102 in Taiwanese [J].
Chen, M. J. ;
Chu, C. C. ;
Shyr, M. H. ;
Lin, P. Y. ;
Yang, K. L. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2008, 35 (01) :15-18
[2]   Sequence-based typing of a novel HLA-DRB1*04 allele, DRB1*0461, in a Taiwanese volunteer marrow donor [J].
Chen, M. J. ;
Chu, C. C. ;
Lin, P. Y. ;
Yang, K. L. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2007, 34 (04) :269-272
[3]   A novel HLA-B allele, B*5214, detected in a Taiwanese volunteer bone marrow donor using a sequence-based typing method [J].
Chen, M. J. ;
Chu, C. C. ;
Shyr, M. H. ;
Lin, C. L. ;
Lin, P. Y. ;
Yang, K. L. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2010, 37 (01) :39-41
[4]   Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded [J].
Chen, M. J. ;
Yang, T. C. ;
Chu, C. C. ;
Shyr, M. H. ;
Lin, C. L. ;
Lin, P. Y. ;
Yang, K. L. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2009, 36 (04) :207-211
[5]   Distributions of human leukocyte antigen-A, -B, and-DRB1 alleles and haplotypes based on 46,915 Taiwanese donors [J].
Lai, Meng-Jiun ;
Wen, Shu-Hui ;
Lin, Ya-Hui ;
Shyr, Ming-Huang ;
Lin, Py-Yu ;
Yang, Kuo-Liang .
HUMAN IMMUNOLOGY, 2010, 71 (08) :777-782
[6]   Nomenclature for factors of the HLA system, 2010 [J].
Marsh, S. G. E. ;
Albert, E. D. ;
Bodmer, W. F. ;
Bontrop, R. E. ;
Dupont, B. ;
Erlich, H. A. ;
Fernandez-Vina, M. ;
Geraghty, D. E. ;
Holdsworth, R. ;
Hurley, C. K. ;
Lau, M. ;
Lee, K. W. ;
Mach, B. ;
Maiers, M. ;
Mayr, W. R. ;
Mueller, C. R. ;
Parham, P. ;
Petersdorf, E. W. ;
Sasazuki, T. ;
Strominger, J. L. ;
Svejgaard, A. ;
Terasaki, P. I. ;
Tiercy, J. M. ;
Trowsdale, J. .
TISSUE ANTIGENS, 2010, 75 (04) :291-455
[7]   The IMGT/HLA database [J].
Robinson, James ;
Mistry, Kavita ;
McWilliam, Hamish ;
Lopez, Rodrigo ;
Parham, Peter ;
Marsh, Steven G. E. .
NUCLEIC ACIDS RESEARCH, 2011, 39 :D1171-D1176
[8]   Human leukocyte antigen-A, -B, and-DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank [J].
Wen, Shu-Hui ;
Lai, Meng-Jiun ;
Yang, Kuo-Liang .
HUMAN IMMUNOLOGY, 2008, 69 (07) :430-436
[9]   Determination of HLA-A, -B and -DRB1 haplotypes based on allelic homozygosity data in selected bone marrow donors of the Taiwanese marrow donor registry [J].
Yang, K. L. ;
Lin, P. Y. .
INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2007, 34 (05) :385-392
[10]   High-resolution human leukocyte antigen (HLA) haplotypes and linkage disequilibrium of HLA-B and -C and HLA-DRB1 and-DQB1 alleles in a Taiwanese population [J].
Yang, Kuo-Liang ;
Chen, Shee-Ping ;
Shyr, Ming-Huang ;
Lin, Py-Yu .
HUMAN IMMUNOLOGY, 2009, 70 (04) :269-276
1