Photoinduced DNA Crosslink Formation by Dichloridooxidovanadium(IV) Complexes of Polypyridyl Bases

被引：11

作者：

Banerjee, Samya ^{[1
]}

Dixit, Akanksha ^{[2
]}

Kumar, Arun ^{[1
]}

Mukherjee, Sanjoy ^{[1
]}

Karande, Anjali A. ^{[2
]}

Chakravarty, Akhil R. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 24期

关键词：

Bioinorganic chemistry; DNA crosslinking; Vanadium; Antitumor agents; Apoptosis; CANCER; REPAIR;

D O I：

10.1002/ejic.201500587

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Oxidovanadium(IV) complexes [VO(pyphen)Cl-2] (1) and [VO(pydppz)Cl-2] (2), where pyphen is 2-(2-pyridyl)-1,10-phenanthroline and pydppz is 3-(pyridin-2-yl)dipyrido[3,2-a:2,3-c]phenazine, show remarkable photoinduced DNA crosslinking ability and photocytotoxicity. The complexes are non-electrolytes in DMF, 1:1 electrolytes in 20% aqueous DMF, and 1:2 electrolytes in 20% aqueous DMF upon photoirradiation with visible light of 400-700 nm. The paramagnetic complexes, which have one unpaired electron, show a d-d band near 780 nm in aqueous DMF. The IR data suggest a V=O moiety trans to a V-N bond. Complex [VO(pydppz)Cl-2] (2), as a novel photoinducible nuclear ds-DNA crosslinking agent, shows visible-light-induced cytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway, giving IC50 values of 0.87 +/- 0.07 and 1.4 +/- 0.2 M, respectively, while being essentially nontoxic (IC50 > 40 M) in the dark and less toxic in normal MCF-10A cells.

引用

页码：3986 / 3990

页数：5