Differential requirements of a mitotic acetyltransferase in somatic and germ line cells

被引：31

作者：

Pimenta-Marques, Ana ^{[1
]}

Tostoes, Rui ^{[1
]}

Marty, Thomas ^{[2
,3
]}

Barbosa, Vitor ^{[2
,3
]}

Lehmann, Ruth ^{[2
,3
]}

Martinho, Rui Goncalo ^{[1
]}

机构：

[1] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal

[2] NYU, Sch Med, Skirball Inst, New York, NY 10016 USA

[3] NYU, Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA

来源：

DEVELOPMENTAL BIOLOGY | 2008年 / 323卷 / 02期

关键词：

Drosophila; Germ line; Oogenesis; Mitosis; Sister chromatid cohesion; Separation anxiety;

D O I：

10.1016/j.ydbio.2008.08.021

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During mitosis different types of cells can have differential requirements for chromosome segregation. We isolated two new alleles of the separation anxiety gene (sun). san was previously described in both Drosophila and in humans to be required for centromeric sister chromatid cohesion (Hou et al., 2007; Williams et al., 2003). Our work confirms and expands the observation that san is required in vivo for normal mitosis of different types of somatic cells. In addition, we suggest that son is also important for the correct resolution of chromosomes, implying a more general function of this acetyltransferase. Surprisingly, during oogenesis we cannot detect mitotic defects in germ line cells mutant for san. We hypothesize the female germ line stem cells have differential requirements for mitotic sister chromatid cohesion. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：197 / 206

页数：10

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