A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis

被引：25
作者：
Ratzlaff, C. [1 ]
Guermazi, A. [2 ]
Collins, J. [1 ]
Katz, J. N. [1 ]
Losina, E. [1 ]
Vanwyngaarden, C.
Russell, R. [1 ]
Iranpour, T. [1 ]
Duryea, J. [1 ]
机构：
[1] Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Boston Univ, Sch Med, Boston, MA 02118 USA
来源：
OSTEOARTHRITIS AND CARTILAGE | 2013年 / 21卷 / 06期
基金：
加拿大健康研究院;
关键词：
Osteoarthritis; Bone marrow lesions; Knee; Magnetic resonance imaging; IMAGING FINDINGS; SEMIQUANTITATIVE ASSESSMENT; CLINICAL-FEATURES; CARTILAGE LOSS; PAIN; DAMAGE; EDEMA; WORMS; BLOKS; SCORE;
D O I：
10.1016/j.joca.2013.03.007
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Purpose: To assess reliability and validity of a semi-automated quantitative method for osteoarthritis (OA)-related bone marrow lesion (BML) assessment in the femur and tibia. Methods: In a cross-sectional study of subjects with knee OA, we examined concurrent criterion and clinical validation of a novel method of semi-automated quantitative BML measurement. The primary outcome was total segmented BML volume in femoral and tibial medial and lateral knee compartments. Criterion validation was examined through comparison of BML volumes with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scoring. Clinical validation was examined via associations of tibial and femoral BML volume with the Western Ontario and McMaster University OA Index weight-bearing pain questions. Results: Among the 115 subjects, mean age was 62 years, mean BMI 30.4 (kg/m(2)), 84% were white and 52% male. The intra-class correlation coefficients (ICC) for intra-reader reliability was 0.96 and 0.97 for inter-reader reliability. Significant Spearman's correlations were found between segmented BML volume and WORMS BML scoring for tibial medial (0.75) and lateral (0.73) compartments, and for femoral medial (0.72) and lateral (0.88) compartments. Significant positive associations were found between weight-bearing pain and total femoral BML volume (P < 0.003), but not total tibial BML (P < 0.101). Conclusion: We have documented a moderately strong correlation between a novel measurement method of femoral and tibial BML volume and semi-quantitative WORMS scores, providing evidence of criterion validity. The hypothesis that weight-bearing pain was associated with BML volume was confirmed for total femoral BML volume but not total tibial BML volume. The lack of association between tibial BML volume and pain requires further investigation. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：806 / 814
页数：9
相关论文
共 40 条
[1]  
ALTMAN RD, 1995, OSTEOARTHR CARTILAGE, V3, P3
[2]  
[Anonymous], OAI CENTR SEM READ K
[3]   Can T2 relaxation values and color maps be used to detect chondral damage utilizing subchondral bone marrow edema as a marker? [J].
Bining, Harjinder J. S. ;
Santos, Rui ;
Andrews, Gordon ;
Forster, Bruce B. .
SKELETAL RADIOLOGY, 2009, 38 (05) :459-465
[4]   Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults [J].
Dore, Dawn ;
Martens, Ashleigh ;
Quinn, Stephen ;
Ding, Changhai ;
Winzenberg, Tania ;
Zhai, Guangju ;
Pelletier, Jean-Pierre ;
Martel-Pelletier, Johanne ;
Abram, Francois ;
Cicuttini, Flavia M. ;
Jones, Graeme .
ARTHRITIS RESEARCH & THERAPY, 2010, 12 (06)
[5]   Quantitative bone marrow lesion size in osteoarthritic knees correlates with cartilage damage and predicts longitudinal cartilage loss [J].
Driban, Jeffrey B. ;
Lo, Grace H. ;
Lee, Ji Yeon ;
Ward, Robert J. ;
Miller, Eric ;
Pang, Jincheng ;
Price, Lori Lyn ;
McAlindon, Timothy E. .
BMC MUSCULOSKELETAL DISORDERS, 2011, 12
[6]   Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study [J].
Englund, Martin ;
Guermazi, Ali ;
Roemer, Frank W. ;
Yang, Mei ;
Zhang, Yuqing ;
Nevitt, Michael C. ;
Lynch, John A. ;
Lewis, Cora E. ;
Torner, James ;
Felson, David T. .
ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (10) :1796-1802
[7]   Comparison of BLOKS and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for osteoarthritis and suggested approach based on their performance: data from the Osteoarthritis Initiative [J].
Felson, D. T. ;
Lynch, J. ;
Guermazi, A. ;
Roemer, F. W. ;
Niu, J. ;
McAlindon, T. ;
Nevitt, M. C. .
OSTEOARTHRITIS AND CARTILAGE, 2010, 18 (11) :1402-1407
[8]   Can anatomic alignment measured from a knee radiograph substitute for mechanical alignment from full limb films? [J].
Felson, D. T. ;
Cooke, T. D. V. ;
Niu, J. ;
Goggins, J. ;
Choi, J. ;
Yu, J. ;
Nevitt, M. C. .
OSTEOARTHRITIS AND CARTILAGE, 2009, 17 (11) :1448-1452
[9]   The association of bone marrow lesions with pain in knee osteoarthritis [J].
Felson, DT ;
Chaisson, CE ;
Hill, CL ;
Totterman, SMS ;
Gale, ME ;
Skinner, KM ;
Kazis, L ;
Gale, DR .
ANNALS OF INTERNAL MEDICINE, 2001, 134 (07) :541-549
[10]   Osteoarthritis of the knee: Comparison of MR imaging findings with radiographic severity measurements and pain in middle-aged women [J].
Hayes, CW ;
Jamadar, DA ;
Welch, GW ;
Jannausch, ML ;
Lachance, LL ;
Capul, DC ;
Sowers, MR .
RADIOLOGY, 2005, 237 (03) :998-1007
1234