No genetic evidence for Neuregulin 3 conferring risk of schizophrenia in the Chinese population

被引：4

作者：

Zhang, Rui ^{[1
,4
]}

Du, Xiao-Yun ^{[1
]}

Yu, Jie ^{[1
]}

Xu, Nan ^{[1
]}

Zheng, Yue-Wen ^{[1
]}

Zhao, Ya-Ling ^{[2
]}

Zhang, Huan ^{[3
]}

Ma, Jie ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Med, Dept Genet & Mol Biol, Xian 710061, Shaanxi, Peoples R China

[2] Xi An Jiao Tong Univ, Sch Med, Dept Epidemiol & Hlth Stat, Xian 710061, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Psychiat, Xian 710004, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp, Xian Hong Hui Hosp, Xian 710054, Shaanxi, Peoples R China

来源：

PSYCHIATRY RESEARCH | 2013年 / 205卷 / 03期

关键词：

Schizophrenia; Neuregulin; 3; SNPs; 3; NRG3; SUSCEPTIBILITY; ASSOCIATION; EXPRESSION; FAMILIES; LINKAGE; SCAN;

D O I：

10.1016/j.psychres.2012.08.017

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We genotyped 13 single nucleotide polymorphisms (SNPs) within Neuregulin 3 (NRG3) to investigate the association between NRG3 and schizophrenia in 488 patients and 506 controls in Northwest China. No association was detected either in SNPs or in haplotypes. Our study provided no evidence that NRG3 confers a risk of schizophrenia susceptibility in the Han Chinese population. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：279 / 281

页数：3

共 16 条

[1] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[2] Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia [J].

Benzel, Isabel ;

Bansal, Aruna ;

Browning, Brian L. ;

Galwey, Nicholas W. ;

Maycox, Peter R. ;

McGinnis, Ralph ;

Smart, Devi ;

St Clair, David ;

Yates, Phillip ;

Purvis, Ian .

BEHAVIORAL AND BRAIN FUNCTIONS, 2007, 3 (1)

[3] Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder [J].

Boer, Simone ;

Berk, Michael ;

Dean, Brian .

NEUROSCIENCE LETTERS, 2009, 466 (01) :27-29

[4] Fine Mapping on Chromosome 10q22-q23 Implicates Neuregulin 3 in Schizophrenia [J].

Chen, Pei-Lung ;

Avramopoulos, Dimitrios ;

Lasseter, Virginia K. ;

McGrath, John A. ;

Fallin, M. Daniele ;

Liang, Kung-Yee ;

Nestadt, Gerald ;

Feng, Ningping ;

Steel, Gary ;

Cutting, Andrew S. ;

Wolyniec, Paula ;

Pulver, Ann E. ;

Valle, David .

AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (01) :21-34

[5] Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22 [J].

Fallin, MD ;

Lasseter, VK ;

Wolyniec, PS ;

McGrath, JA ;

Nestadt, G ;

Valle, D ;

Liang, KY ;

Pulver, AE .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (03) :601-611

[6] Genome scan of Han Chinese schizophrenia families from Taiwan: Confirmation of linkage to 10q22.3 [J].

Faraone, Stephen V. ;

Hwu, Hai-Gwo ;

Liu, Chih-Min ;

Chen, Wei J. ;

Tsuang, Ming-Ming ;

Liu, Shih-Kai ;

Shieh, Ming-Hsien ;

Hwang, Tzung-Jeng ;

Ou-Yang, Wen-Chen ;

Chen, Chun-Ying ;

Chen, Chwen-Cheng ;

Lin, Jin-Jia ;

Chou, Frank Huang-Chih ;

Chueh, Ching-Mo ;

Liu, Wei-Ming ;

Hall, Mei-Hua ;

Su, Jessica ;

Van Eerdewegh, Paul ;

Tsuang, Ming T. .

AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (10) :1760-1766

[7] G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences [J].

Faul, Franz ;

Erdfelder, Edgar ;

Lang, Albert-Georg ;

Buchner, Axel .

BEHAVIOR RESEARCH METHODS, 2007, 39 (02) :175-191

[8] Neuregulin 1 and schizophrenia: Genetics, gene expression, and neurobiology [J].

Harrison, Paul J. ;

Law, Amanda J. .

BIOLOGICAL PSYCHIATRY, 2006, 60 (02) :132-140

[9] Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain [J].

Kao, Wee-Tin ;

Wang, Yanhong ;

Kleinman, Joel E. ;

Lipska, Barbara K. ;

Hyde, Thomas M. ;

Weinberger, Daniel R. ;

Law, Amanda J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (35) :15619-15624

[10] Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia [J].

Li, Dawei ;

Collier, David A. ;

He, Lin .

HUMAN MOLECULAR GENETICS, 2006, 15 (12) :1995-2002

← 1 2 →