Image Quality and Stenosis Assessment of Non-Contrast-Enhanced 3-T Magnetic Resonance Angiography in Patients with Peripheral Artery Disease Compared with Contrast-Enhanced Magnetic Resonance Angiography and Digital Subtraction Angiography

被引:8
作者
Liu, Jiayi [1 ]
Zhang, Nan [1 ]
Fang, Zhaoyang [2 ]
Luo, Nan [1 ]
Zhao, Yike [1 ]
Bi, Xiaoming [2 ]
An, Jing [3 ]
Chen, Zhong [4 ]
Liu, Dongting [1 ]
Wen, Zhaoying [1 ]
Fan, Zhanming [1 ]
Li, Debiao [2 ]
机构
[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Radiol, Chaoyang Dist Anzhen Rd 2nd, Beijing 100029, Peoples R China
[2] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA
[3] Siemens Healthcare, MR Collaborat NE Asia, Beijing, Peoples R China
[4] Capital Med Univ, Beijing Anzhen Hosp, Dept Vasc Surg, Chaoyang Dist Anzhen Rd 2nd, Beijing 100029, Peoples R China
来源
PLOS ONE | 2016年 / 11卷 / 11期
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
INFLOW SINGLE-SHOT; MR-ANGIOGRAPHY; TECHNICAL CONSIDERATIONS; INITIAL-EXPERIENCE;
D O I
10.1371/journal.pone.0166467
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose To evaluate the diagnostic performance of flow-sensitive dephasing (FSD)-prepared steady-state free precession (SSFP) magnetic resonance angiography (MRA) at 3 T for imaging infragenual arteries relative to contrast-enhanced MRA (CE-MRA) and digital subtraction angiography (DSA). Materials and Methods A series of 16 consecutive patients with peripheral arterial disease (PAD) underwent a combined peripheral MRA protocol consisting of FSD-MRA for the calves and large field-of-view CE-MRA. DSA was performed on all patients within 1 week of the MR angiographies. Image quality and degree of stenosis was assessed by two readers with rich experience. Interobserver agreement was determined using kappa statistics. Receiver operating characteristic (ROC) curve analysis determined the diagnostic value of FSD-MRA, CE-MRA, and CE-MRA combined with FSD-MRA (CE+ FSD MRA) in predicting vascular stenosis. Results At the calf station, no significantly difference of subjective image quality scores was found between FSD-MRA and CE-MRA. Inter-reader agreement was excellent for both FSD-MRA and CE-MRA. Both of FSD-MRA and CE-MRA carry a stenosis overestimation risk relative to DSA standard. With DSA as the reference standard, ROC curve analysis showed that the area under the curve was largest for CE+FSD MRA. The greatest sensitivity and specificity were obtained when a cut-off stenosis score of 2 was used. Conclusion In patients with severe PAD, 3 T FSD-MRA provides good-quality diagnostic images without a contrast agent and is a good supplement for CE-MRA. CE+FSD MRA can improve the accuracy of vascular stenosis diagnosis.
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页数:13
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