The effect of vaccination to dendritic cell and immune cell interaction in HIV disease progression

被引：10
|
作者：
Roy, Priti Kumar [1 ]
Chatterjee, Amar Nath [1 ]
Li, Xue-Zhi [2 ]
机构：
[1] Jadavpur Univ, Dept Math, Ctr Math Biol & Ecol, Kolkata 700032, India
[2] Xinyang Normal Univ, Coll Math & Informat Sci, Xinyang 464000, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOMATHEMATICS | 2016年 / 9卷 / 01期
基金：
中国国家自然科学基金;
关键词：
HIV; dendritic cell; DC-based immune therapy; first-order elimination; Michaelis-Menten elimination; IMMUNOLOGICAL MODEL; DRUG; INFECTION; DYNAMICS; PROTEASE; THERAPY;
D O I：
10.1142/S1793524516500054
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this research paper, our main objective is to find out the meticulous role of activated dendritic cells (DCs) during the human immunodeficiency virus (HIV) infection process. DCs play a dual role by enhancing both HIV infection progression, as well as antiviral immune response. To explore the implications of these dual roles, we have formulated our mathematical model and analyzed the model by both analytical and numerical approaches. By using an impulsive differential equation, we have studied the effect of DC-based vaccination. Analytically we have determined the threshold value of drug dosage and dosing interval for optimum levels of infection. We have also investigated the effect of perfect adherence of drug dose on the immune cell count in extreme cases and observed that, systematic drug dose of the immune cells leads to its maximum level.
引用
收藏
页数：20
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