Genetics of pancreatic cancer and implications for therapy

被引：11

作者：

Bhosale, Priya ^{[1
]}

Cox, Veronica ^{[1
]}

Faria, Silvana ^{[1
]}

Javadi, Sanaz ^{[1
]}

Viswanathan, Chitra ^{[1
]}

Koay, Eugene ^{[2
]}

Tamm, Eric ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, Unit 38,1515 Holcombe Blvd, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

ABDOMINAL RADIOLOGY | 2018年 / 43卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Pancreatic cancer; Genomics; Imaging Mutations; HEREDITARY PANCREATITIS; INTRAEPITHELIAL NEOPLASIA; BRCA MUTATION; CLINICAL CHARACTERISTICS; SOMATIC MUTATIONS; FAMILY-HISTORY; RISK-FACTORS; PHASE-II; ADENOCARCINOMA; GEMCITABINE;

D O I：

10.1007/s00261-017-1394-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Pancreatic cancer is a highly lethal disease with a dismal 5-year prognosis. Knowledge of its genetics may help in identifying new methods for patient screening, and cancer treatment. In this review, we will describe the most common mutations responsible for the genesis of pancreatic cancer and their impact on screening, patterns of disease progression, and therapy.

引用

页码：404 / 414

页数：11

共 78 条

[1] Family History of Diabetes and Pancreatic Cancer as Risk Factors for Pancreatic Cancer: The PACIFIC Study [J].

Austin, Melissa A. ;

Kuo, Elena ;

Van Den Eeden, Stephen K. ;

Mandelson, Margaret T. ;

Brentnall, Teresa A. ;

Kamineni, Aruna ;

Potter, John D. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2013, 22 (10) :1913-1917

[2] Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations [J].

Barrow, E. ;

Robinson, L. ;

Alduaij, W. ;

Shenton, A. ;

Clancy, T. ;

Lalloo, F. ;

Hill, J. ;

Evans, D. G. .

CLINICAL GENETICS, 2009, 75 (02) :141-149

[3] Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma [J].

Beger, C ;

Ramadani, M ;

Meyer, S ;

Leder, G ;

Krüger, M ;

Welte, K ;

Gansauge, F ;

Beger, HG .

CLINICAL CANCER RESEARCH, 2004, 10 (11) :3780-3787

[4] Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes [J].

Biankin, Andrew V. ;

Waddell, Nicola ;

Kassahn, Karin S. ;

Gingras, Marie-Claude ;

Muthuswamy, Lakshmi B. ;

Johns, Amber L. ;

Miller, David K. ;

Wilson, Peter J. ;

Patch, Ann-Marie ;

Wu, Jianmin ;

Chang, David K. ;

Cowley, Mark J. ;

Gardiner, Brooke B. ;

Song, Sarah ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Nourse, Craig ;

Nourbakhsh, Ehsan ;

Manning, Suzanne ;

Wani, Shivangi ;

Gongora, Milena ;

Pajic, Marina ;

Scarlett, Christopher J. ;

Gill, Anthony J. ;

Pinho, Andreia V. ;

Rooman, Ilse ;

Anderson, Matthew ;

Holmes, Oliver ;

Leonard, Conrad ;

Taylor, Darrin ;

Wood, Scott ;

Xu, Qinying ;

Nones, Katia ;

Fink, J. Lynn ;

Christ, Angelika ;

Bruxner, Tim ;

Cloonan, Nicole ;

Kolle, Gabriel ;

Newell, Felicity ;

Pinese, Mark ;

Mead, R. Scott ;

Humphris, Jeremy L. ;

Kaplan, Warren ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chou, Angela ;

Chin, Venessa T. ;

Chantrill, Lorraine A. .

NATURE, 2012, 491 (7424) :399-405

[5] SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer [J].

Blackford, Amanda ;

Serrano, Oscar K. ;

Wolfgang, Christopher L. ;

Parmigiani, Giovanni ;

Jones, Sian ;

Zhang, Xiaosong ;

Parsons, D. Williams ;

Lin, Jimmy Cheng-Ho ;

Leary, Rebecca J. ;

Eshleman, James R. ;

Goggins, Michael ;

Jaffee, Elizabeth M. ;

Iacobuzio-Donahue, Christine A. ;

Maitra, Anirban ;

Cameron, John L. ;

Olino, Kelly ;

Schulick, Richard ;

Winter, Jordan ;

Herman, Joseph M. ;

Laheru, Daniel ;

Klein, Alison P. ;

Vogelstein, Bert ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Hruban, Ralph H. .

CLINICAL CANCER RESEARCH, 2009, 15 (14) :4674-4679

[6] A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy [J].

Bodoky, Gyoergy ;

Timcheva, Constanta ;

Spigel, David Robert ;

La Stella, Phillip Joseph ;

Ciuleanu, Tudor Eliade ;

Pover, G. ;

Tebbutt, N. C. .

INVESTIGATIONAL NEW DRUGS, 2012, 30 (03) :1216-1223

[7] Loss of SMAD4 Staining in Pre-Operative Cell Blocks is Associated With Distant Metastases Following Pancreaticoduodenectomy With Venous Resection for Pancreatic Cancer [J].

Boone, Brian A. ;

Sabbaghian, Shirin ;

Zenati, Mazen ;

Marsh, J. Wallis ;

Moser, A. James ;

Zureikat, Amer H. ;

Singhi, Aatur D. ;

Zeh, Herbert J., III ;

Krasinskas, Alyssa M. .

JOURNAL OF SURGICAL ONCOLOGY, 2014, 110 (02) :171-175

[8] Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities [J].

Bournet, Barbara ;

Buscail, Camille ;

Muscari, Fabrice ;

Cordelier, Pierre ;

Buscail, Louis .

EUROPEAN JOURNAL OF CANCER, 2016, 54 :75-83

[9] Advances in counselling and surveillance patients at risk for pancreatic cancer [J].

Brand, Randall E. ;

Lerch, Markus M. ;

Rubinstein, Wendy S. ;

Neoptolemos, John P. ;

Whitcomb, David C. ;

Hruban, Ralph H. ;

Brentnall, Teresa A. ;

Lynch, Henry T. ;

Canto, Marcia I. .

GUT, 2007, 56 (10) :1460-1469

[10] Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas [J].

Brat, DJ ;

Lillemoe, KD ;

Yeo, CJ ;

Warfield, PB ;

Hruban, RH .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1998, 22 (02) :163-169

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