Amine-boranes:: effective reducing agents for the deracemisation of DL-amino acids using L-amino acid oxidase from Proteus myxofaciens

被引:88
作者
Alexandre, FR
Pantaleone, DP
Taylor, PP
Fotheringham, IG
Ager, DJ
Turner, NJ
机构
[1] Univ Edinburgh, Dept Chem, Ctr Prot Technol, Edinburgh EH9 3JJ, Midlothian, Scotland
[2] Great Lakes Fine Chem, Mt Prospect, IL 60056 USA
[3] MediChem Res Inc, Woodridge, IL 60517 USA
关键词
amine borane; D-amino acid; L-amino acid oxidase; deracemisation;
D O I
10.1016/S0040-4039(01)02233-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The deracemisation of DL-alpha-aluino acids using L-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of D-amino acids were obtained in yields of up to 90%, and e.c. >99%. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:707 / 710
页数:4
相关论文
共 19 条