Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

被引:24
作者
Chan, Deva D. [1 ]
Neu, Corey P. [1 ]
机构
[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA
基金
美国国家科学基金会;
关键词
tissue damage and disease; quantitative imaging; magnetic resonance relaxometry; articular cartilage; arthritis and osteoarthritis; GADOLINIUM-ENHANCED MRI; T2; RELAXATION-TIME; HUMAN KNEE CARTILAGE; IN-VIVO ASSESSMENT; PROTEOGLYCAN DEPLETION; PATELLAR CARTILAGE; HYALINE CARTILAGE; BIOCHEMICAL-PROPERTIES; EXTRACELLULAR-MATRIX; DEGENERATIVE CHANGES;
D O I
10.1098/rsif.2012.0608
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical, biomechanical, metabolic and genetic factors, which are often triggered by injury, and mediated by inflammation, catabolic cytokines and enzymes. An unmet clinical need is the lack of reliable methods that are able to probe the pathogenesis of early OA when disease-rectifying therapies may be most effective. Non-invasive quantitative magnetic resonance imaging (qMRI) techniques have shown potential for characterizing the structural, biochemical and mechanical changes that occur with cartilage degeneration. In this paper, we review the background in articular cartilage and OA as it pertains to conventional MRI and qMRI techniques. We then discuss how conventional MRI and qMRI techniques are used in clinical and research environments to evaluate biochemical and mechanical changes associated with degeneration. Some qMRI techniques allow for the use of relaxometry values as indirect biomarkers for cartilage components. Direct characterization of mechanical behaviour of cartilage is possible via other specialized qMRI techniques. The combination of these qMRI techniques has the potential to fully characterize the biochemical and biomechanical states that represent the initial changes associated with cartilage degeneration. Additionally, knowledge of in vivo cartilage biochemistry and mechanical behaviour in healthy subjects and across a spectrum of osteoarthritic patients could lead to improvements in the detection, management and treatment of OA.
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页数:11
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