Alveolar macrophage in the driver's seat

被引:180
作者
Lambrecht, BN [1 ]
机构
[1] Erasmus Univ, Med Ctr, Dept Pulm Med, NL-3015 GE Rotterdam, Netherlands
关键词
D O I
10.1016/j.immuni.2006.03.008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although alveolar macrophages are normally quiescent to prevent damaging the alveoli, in this issue of Immunity, Takabayshi et al. (2006) demonstrate that alveolar macrophages can self-regulate their function on demand to mount an appropriate immune response.
引用
收藏
页码:366 / 368
页数:3
相关论文
共 9 条
[1]   INHIBITION OF THE IMMUNOSUPPRESSIVE ACTIVITY OF RESIDENT PULMONARY ALVEOLAR MACROPHAGES BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR [J].
BILYK, N ;
HOLT, PG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1773-1777
[2]   Runx3 regulates mouse TGF-β-mediated dendritic cell function and its absence results in airway inflammation [J].
Fainaru, O ;
Woolf, E ;
Lotem, J ;
Yarmus, M ;
Brenner, O ;
Goldenberg, D ;
Negreanu, V ;
Bernstein, Y ;
Levanon, D ;
Jung, S ;
Groner, Y .
EMBO JOURNAL, 2004, 23 (04) :969-979
[3]   Medical progress: Idiopathic pulmonary fibrosis. [J].
Gross, TJ ;
Hunninghake, GW .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (07) :517-525
[4]   DOWN-REGULATION OF THE ANTIGEN PRESENTING CELL FUNCTION(S) OF PULMONARY DENDRITIC CELLS INVIVO BY RESIDENT ALVEOLAR MACROPHAGES [J].
HOLT, PG ;
OLIVER, J ;
BILYK, N ;
MCMENAMIN, C ;
MCMENAMIN, PG ;
KRAAL, G ;
THEPEN, T .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :397-407
[5]   INHIBITORY ACTIVITY OF UNSTIMULATED ALVEOLAR MACROPHAGES ON T-LYMPHOCYTE BLASTOGENIC RESPONSE [J].
HOLT, PG .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1978, 118 (04) :791-793
[6]  
MacLean JA, 1996, AM J PATHOL, V148, P657
[7]   Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema [J].
Morris, DG ;
Huang, XZ ;
Kaminski, N ;
Wang, YN ;
Shapiro, SD ;
Dolganov, G ;
Glick, A ;
Sheppard, D .
NATURE, 2003, 422 (6928) :169-173
[8]  
THEPEN T, 1989, J EXP MED, V170, P494
[9]   Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation - Analysis of cellular recruitment and cytokine responses [J].
Warmington, KS ;
Boring, L ;
Ruth, JH ;
Sonstein, J ;
Hogaboam, CM ;
Curtis, JL ;
Kunkel, SL ;
Charo, IR ;
Chensue, SW .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (05) :1407-1416