Detection of hydroxyethylstarch (HES) in human urine by liquid chromatography-mass spectrometry

被引：12

作者：

Deventer, K ^{[1
]}

Van Eenoo, P ^{[1
]}

Delbeke, FT ^{[1
]}

机构：

[1] Univ Ghent, Dept Clin Chem Microbiol & Immunol, DoCoLab, B-9052 Zwijnaarde, Belgium

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2006年 / 834卷 / 1-2期

关键词：

doping; liquid chromatography; mass spectrometry; HES; urine; glucose;

D O I：

10.1016/j.jchromb.2006.02.044

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this study was to establish the possibility of using liquid chromatography coupled to mass spectrometry for the detection of hydroxyethyl starch (a corn starch derived product) in urine as an alternative to the current time consuming GC-MS methods. Analyses were performed using an ion trap instrument after acidic hydrolysis. Ionization was carried out using atmospheric pressure chemical ionisation (APCI) Ms-2. The results indicate that the developed method can successfully be applied as a fast and reliable method for the detection and identification of hydroxyethyl starch. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：217 / 220

页数：4

共 12 条

[11] Detection of the plasma volume expander hydroxyethyl starch in human urine [J].

Thevis, M ;

Opfermann, G ;

Schänzer, W .

JOURNAL OF CHROMATOGRAPHY B, 2000, 744 (02) :345-350

[12] Hydroxyethyl starch in balanced electrolyte solution (Hextend®)-pharmacokinetic and pharmacodynamic profiles in healthy volunteers [J].

Wilkes, NJ ;

Woolf, RL ;

Powanda, MC ;

Gan, TJ ;

Machin, SJ ;

Webb, A ;

Mutch, M ;

Bennett-Guerrero, E ;

Mythen, M .

ANESTHESIA AND ANALGESIA, 2002, 94 (03) :538-544

← 1 2 →