Uterine Natural Killer Cells

被引：124

作者：

Sojka, Dorothy K. ^{[1
]}

Yang, Liping ^{[1
]}

Yokoyama, Wayne M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Div Rheumatol, St Louis, MO 63110 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

美国国家卫生研究院;

关键词：

uterine natural killer cells; pregnancy; tissue-resident natural killer cells; placenta; maternal-fetal interface; uterine innate lymphoid cells; conventional natural killer cells; INNATE LYMPHOID-CELLS; INTERFERON-GAMMA CONTRIBUTES; METRIAL GLAND; NK CELLS; MURINE; DIFFERENTIATION; PREGNANCY; TROPHOBLAST; MICE; PREECLAMPSIA;

D O I：

10.3389/fimmu.2019.00960

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells (ILCs). While most previously studied NK cells were derived from the mouse spleen and circulate in the blood, recently others and we found tissue-resident NK (trNK) cells in many tissues that resemble group 1 ILCs (ILC1s). During pregnancy, NK cells are themost abundant lymphocytes in the uterus at the maternal-fetal interface and are involved in placental vascular remodeling. Prior studies suggested that these uterine NK (uNK) cells are mostly derived from circulating NK cells. However, the murine virgin uterus contains mostly trNK cells and it has been challenging to determine their contribution to uNK cells in pregnancy as well as other potential function(s) of uNK cells due to the dynamic microenvironment in the pregnant uterus. This reviewfocuses on the origins and functions of the heterogeneous populations of uNK cells during the course of murine pregnancy.

引用

页数：9

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