Hepatitis B virus (HBV) mutations associated with resistance to lamivudine in patients coinfected with HBV and human immunodeficiency virus

被引：56
|
作者：
Thibault, V [1 ]
Benhamou, Y [1 ]
Seguret, C [1 ]
Bochet, M [1 ]
Katlama, C [1 ]
Bricaire, F [1 ]
Opolon, P [1 ]
Poynard, T [1 ]
Agut, H [1 ]
机构：
[1] Grp Hosp Pitie Salpetriere, Lab Virol CERVI, Serv Hepatogastroenterol, Serv Malad Infect, F-75013 Paris, France
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 1999年 / 37卷 / 09期
关键词：
D O I：
10.1128/JCM.37.9.3013-3016.1999
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Mutations associated with hepatitis B virus (HBV) resistance to lamivudine have not been extensively addressed in human immunodeficiency virus (HIV)-HBV coinfection. We have studied the HBV polymerase sequences from nine coinfected patients who experienced HBV recurrence while under lamivudine treatment. In seven of these nine patients, Met(550), belonging to the highly conserved YMDD motif, was mutated to Val and was associated with a substitution of Met for Leu(526) in each case. In the two remaining patients, we found a Met(550)-to-Ile change that was associated in only one case with a Leu(526)-to-Met mutation. No mutation was observed in three control patients not receiving lamivudine. This study demonstrates the emergence of particular genetic profiles in HBV-HIV-coinfected patients experiencing a loss of control of HBV infection despite high doses of lamivudine.
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收藏
页码：3013 / 3016
页数：4
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